@article{oai:niigata-u.repo.nii.ac.jp:00014856,
 author = {松原, 琢 and 堀, 知行 and 尾崎, 和幸 and 中川, 巌 and 今井, 俊介 and 相澤, 義房},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {Coronary endothelial dysfunction is important not only for the progression of atherosclerosis but also for the trigger of plaque disruption. The rupture of plaques is now considered to be the common pathophysiological substrate of the acute coronary syndromes that include unstable angina, acute myocardial infarction and sudden ischemic death. To examine whether or not the levels of NOx (nitrite and nitrate) and thrombomodulin (TM) in coronary circulating blood reflect endothelial dysfunction in coronary atherosclerosis, the levels in plasma obtained from ostium of left coronary artery and coronary sinus of patients who complained of chest pain were evaluated in relation to their coronary angiographic findings. Our study revealed a decreased NOx level and an increased TM level in coronary circulation in patients with severe coronary atherosclerosis implying severe coronary endothelial dysfunction. There is a possibility that the local therapy for the coronary segments where coronary endothelial function is severely impaired may contribute to the prevention of the acute coronary syndromes.},
 pages = {224--226},
 title = {2)冠動脈疾患の病態における血栓症の関与（シンポジウム 各科領域における血栓症）},
 volume = {115},
 year = {2001}
}