{"created":"2021-03-01T06:19:19.344731+00:00","id":14855,"links":{},"metadata":{"_buckets":{"deposit":"8941428f-2a5d-49c1-9d26-7327a8d068c6"},"_deposit":{"id":"14855","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14855"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00014855","sets":["453:456","471:537:538:1074"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Pathogenesis and Pathophysiological Analysis of Thrombophilia（Thrombosis in Individual Medical Fields）"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"223","bibliographicPageStart":"219","bibliographicVolumeNumber":"115","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Numerous risk factors, both genetic and acquired, have been associated with thrombophilia. Inherited thrombophilia includes deficiencies or qualitative abnormalities of natural anticoagulants (antithrombin, protein C and protein S), activated protein C resistance and fibrinolytic defects, as well as genetic polymorphism such as prothrombin G20210A, the promotor region of plasminogen activator inhibitor-1 gene (4G/5G) and homocysteine-related, methylene tetrahydrofolate reductase (MTHFR) polymorphism. Acquired thrombotic tendencies comprise a diverse group of clinical conditions, such as malignancy, pregnancy, myeloproliferative disorders, hyperlipidemia, prolonged immobility, obesity, major surgery, and artificial surfaces. These disorders are complex and usually show several hemostatic abnormalities. The hemostatic molecular markers are useful for evaluation of the prethrombotic states and thrombotic activity of thrombotic diseases. High plasma levels of thrombin-antithrombin complex (TAT), prothrombin fragment 1+2 (F1+2) and plasmin-plasmin inhibitor complex (PIC) indicated that excessive activation of coagulation and fibrinolysis actually occurs in the majority of patients with thrombotic disease, especially in patients with deep vein thrombosis and pulmonary embolism.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"95778","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takahashi, Hoyu"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 芳右"}],"nameIdentifiers":[{"nameIdentifier":"95777","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"115(6)_219-223.pdf","filesize":[{"value":"858.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"115(6)_219-223.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/14855/files/115(6)_219-223.pdf"},"version_id":"7160b451-c1a0-4bd3-9327-2330a3a8f906"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"thrombophilia","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombotic risk factor","subitem_subject_scheme":"Other"},{"subitem_subject":"genetic polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"hemostatic molecular marker","subitem_subject_scheme":"Other"},{"subitem_subject":"血栓傾向","subitem_subject_scheme":"Other"},{"subitem_subject":"血栓症危険因子","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子多型","subitem_subject_scheme":"Other"},{"subitem_subject":"凝血学的分子マーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"1)血栓傾向の原因と病態解析（シンポジウム 各科領域における血栓症）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1)血栓傾向の原因と病態解析（シンポジウム 各科領域における血栓症）"},{"subitem_title":"1)血栓傾向の原因と病態解析（シンポジウム 各科領域における血栓症）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1074"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-09"},"publish_date":"2017-11-09","publish_status":"0","recid":"14855","relation_version_is_last":true,"title":["1)血栓傾向の原因と病態解析（シンポジウム 各科領域における血栓症）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:46:44.580727+00:00"}