@article{oai:niigata-u.repo.nii.ac.jp:00014855, author = {高橋, 芳右}, issue = {6}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Jun}, note = {Numerous risk factors, both genetic and acquired, have been associated with thrombophilia. Inherited thrombophilia includes deficiencies or qualitative abnormalities of natural anticoagulants (antithrombin, protein C and protein S), activated protein C resistance and fibrinolytic defects, as well as genetic polymorphism such as prothrombin G20210A, the promotor region of plasminogen activator inhibitor-1 gene (4G/5G) and homocysteine-related, methylene tetrahydrofolate reductase (MTHFR) polymorphism. Acquired thrombotic tendencies comprise a diverse group of clinical conditions, such as malignancy, pregnancy, myeloproliferative disorders, hyperlipidemia, prolonged immobility, obesity, major surgery, and artificial surfaces. These disorders are complex and usually show several hemostatic abnormalities. The hemostatic molecular markers are useful for evaluation of the prethrombotic states and thrombotic activity of thrombotic diseases. High plasma levels of thrombin-antithrombin complex (TAT), prothrombin fragment 1+2 (F1+2) and plasmin-plasmin inhibitor complex (PIC) indicated that excessive activation of coagulation and fibrinolysis actually occurs in the majority of patients with thrombotic disease, especially in patients with deep vein thrombosis and pulmonary embolism.}, pages = {219--223}, title = {1)血栓傾向の原因と病態解析(シンポジウム 各科領域における血栓症)}, volume = {115}, year = {2001} }