{"created":"2021-03-01T06:19:15.887253+00:00","id":14801,"links":{},"metadata":{"_buckets":{"deposit":"f9e7da85-d2f1-475c-b19b-1309687a8731"},"_deposit":{"id":"14801","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14801"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00014801","sets":["453:456","471:537:538:1073"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Relationships Among Immune Complex Deposition, Inflammatory Cell Infiltrate, E-selectin Expression of Vascular Endothelial Cells and Mast Cell Degranulation in Anaphylactoid Purpura"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"305","bibliographicPageStart":"293","bibliographicVolumeNumber":"115","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, skin biopsy specimens from forty-nine patients with anaphylactoid purpura (AP) were immunohistochemically examined, using avidin and anti c-kit antibody for mast cell staining, Ulex europaeus agglutinin-1 lectin, anti α-smooth muscle actin antibody and anti type IV collagen antibody for blood vessels, propidium iodide for nuclear staining, anti E-selectin antibody for E-selectin expression, and anti IgA antibody for immune complex (IC). The relationships among IC deposition, inflammatory cell infiltrate, E-selectin expression in endothelial cells and mast cell degranulation in the disease were analyzed with confocal laser scanning microscopy. IgA is always deposited mainly in capillary loop, but in most of the lesions examined only a small amount of inflammatory cell infiltrate is observed in the blood vessels. E-selectin was expressed in endothelial cells of blood vessels in fifteen of thirty-two patients (46.9%). Most blood vessels with E-selectin-positive endothelial cells were the horizontal plexus, and dense inflammatory cell infiltrate was always observed around the blood vessels. In lesions from seven patients the number of avidin-binding cells around blood vessels was inversely proportional to the density of inflammatory cell infiltrate. In historogically uninvolved site from four of them, the number of avidine-binding cells was significantly decreased compared with normal skin. However, there was no significant difference in the number of c-kit positive cells between involved and uninvolved vessels from all of the four patients. In addition, fluorescence intensity of avidin-binding granules was much decreased in involved vessels compared with uninvolved one. In capillary loop in skin lesions from nine patients, there was no difference in the number of avidin-binding cells between lgA positive and negative vessels. Fluorescene intensity of avidin-binding cells was markedly decreased around the E-selection-expressed vessels. These data suggest that  (1) mast cell degranulation occurres during the early stages of vasculitis, even before the inflammatory cell infiltrate ; (2)IgA-containing immune complexes per se is not sufficient for mast cell degranulation; (3) E-selectin-expression, which is localized mainly in horizontal plexus, is associated with must cell degranulation and may induce infiltration of neutrophills.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"95426","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tago, Osamu"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田子, 修"}],"nameIdentifiers":[{"nameIdentifier":"95425","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"115(7)_293-305.pdf","filesize":[{"value":"3.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"115(7)_293-305.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/14801/files/115(7)_293-305.pdf"},"version_id":"6401104a-8d93-48d6-8c24-3d81fc8a7e0b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anaphylactoid purpura","subitem_subject_scheme":"Other"},{"subitem_subject":"mast cells","subitem_subject_scheme":"Other"},{"subitem_subject":"immune complex","subitem_subject_scheme":"Other"},{"subitem_subject":"E-selectin","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory cell infiltrate","subitem_subject_scheme":"Other"},{"subitem_subject":"confocal laser scanning microscopy","subitem_subject_scheme":"Other"},{"subitem_subject":"アナフィラクトイド紫斑","subitem_subject_scheme":"Other"},{"subitem_subject":"肥満細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫複合体","subitem_subject_scheme":"Other"},{"subitem_subject":"E-セレクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症細胞浸潤","subitem_subject_scheme":"Other"},{"subitem_subject":"共焦点レーザー走査型顕微鏡","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アナフィラクトイド紫斑における免疫複合体, 炎症細胞浸潤, E-セレクチンと肥満細胞の脱顆粒の関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アナフィラクトイド紫斑における免疫複合体, 炎症細胞浸潤, E-セレクチンと肥満細胞の脱顆粒の関係"},{"subitem_title":"アナフィラクトイド紫斑における免疫複合体, 炎症細胞浸潤, E-セレクチンと肥満細胞の脱顆粒の関係","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1073"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-09"},"publish_date":"2017-11-09","publish_status":"0","recid":"14801","relation_version_is_last":true,"title":["アナフィラクトイド紫斑における免疫複合体, 炎症細胞浸潤, E-セレクチンと肥満細胞の脱顆粒の関係"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:46:43.355248+00:00"}