{"created":"2021-03-01T06:19:11.193446+00:00","id":14728,"links":{},"metadata":{"_buckets":{"deposit":"d195787c-8f26-4979-b29e-856a2d4df0ca"},"_deposit":{"id":"14728","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14728"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00014728"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of NMDA Receptor Localization at the Mossy Fiber-Granule Cell Synapse in the Cerebellum"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"475","bibliographicPageStart":"464","bibliographicVolumeNumber":"115","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"NMDA receptors are critical for synaptic plasticity and neuronal development. They are complexes consisting of the GluR\u03b61 (NR 1) subunits and one or more GluR\u03b5 (\u03b5 1-4 or NR 2 A-D) subunits. Although their synaptic localization is physiologically important in neural activities, the mechanism underlying synaptic targeting, subcellular localization, and cell surface expression remains largely unknown. To understand the synaptic localization of the NMDA receptor in cerebellum, I generated mutant mice lacking both GluR\u03b51and \u03b53subunits, and made immunohistochemical and biochemical analysis in the cerebellum. There was little immunoreactivity for the GluR g 1 subunit in the granular layer of GluR\u03b5 1/\u03b53 mutant cerebellum, while the GluR\u03b61, \u03b51, and \u03b53 subunits were found to be localized at the cerebellar glomerulus in wildtype mouse. The amount of GluR\u03b61 protein in the GluR\u03b51/\u03b53 mutant cerebellum was greatly reduced and hardly enriched in PSD fraction. These results indicate that the GluR e subunits serve as determinants of synaptic localization and protein stabilization of the GluR\u03b61 subunit in vivo.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"95001","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abe, Manabu"}]}]},"item_7_publisher_7":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"\u65b0\u6f5f\u533b\u5b66\u4f1a"}]},"item_7_select_19":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"\u963f\u90e8, \u5b66"}],"nameIdentifiers":[{"nameIdentifier":"95000","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"115(9)_464-475.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"115(9)_464-475.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/14728/files/115(9)_464-475.pdf"},"version_id":"94b76a23-afac-4877-9258-ed2c70d419a7"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"NMDA receptor channel","subitem_subject_scheme":"Other"},{"subitem_subject":"\u03b61 subunit","subitem_subject_scheme":"Other"},{"subitem_subject":"\u03b5 subunits","subitem_subject_scheme":"Other"},{"subitem_subject":"gene targeting","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"synaptic localization","subitem_subject_scheme":"Other"},{"subitem_subject":"NMDA\u53d7\u5bb9\u4f53\u30c1\u30e3\u30cd\u30eb","subitem_subject_scheme":"Other"},{"subitem_subject":"\u03b61\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8","subitem_subject_scheme":"Other"},{"subitem_subject":"\u03b5\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8","subitem_subject_scheme":"Other"},{"subitem_subject":"\u30b8\u30fc\u30f3\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0","subitem_subject_scheme":"Other"},{"subitem_subject":"\u514d\u75ab\u7d44\u7e54\u5316\u5b66","subitem_subject_scheme":"Other"},{"subitem_subject":"\u30b7\u30ca\u30d7\u30b9\u5c40\u5728","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"\u82d4\u72b6\u7dda\u7dad : \u5c0f\u8133\u9846\u7c92\u7d30\u80de\u30b7\u30ca\u30d7\u30b9\u306b\u304a\u3051\u308bNMDA\u53d7\u5bb9\u4f53\u306e\u5c40\u5728\u6a5f\u69cb\u306e\u89e3\u6790","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"\u82d4\u72b6\u7dda\u7dad : \u5c0f\u8133\u9846\u7c92\u7d30\u80de\u30b7\u30ca\u30d7\u30b9\u306b\u304a\u3051\u308bNMDA\u53d7\u5bb9\u4f53\u306e\u5c40\u5728\u6a5f\u69cb\u306e\u89e3\u6790"},{"subitem_title":"\u82d4\u72b6\u7dda\u7dad : \u5c0f\u8133\u9846\u7c92\u7d30\u80de\u30b7\u30ca\u30d7\u30b9\u306b\u304a\u3051\u308bNMDA\u53d7\u5bb9\u4f53\u306e\u5c40\u5728\u6a5f\u69cb\u306e\u89e3\u6790","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["453/456","471/537/538/1071"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2017-11-09"},"publish_date":"2017-11-09","publish_status":"0","recid":"14728","relation_version_is_last":true,"title":["\u82d4\u72b6\u7dda\u7dad : \u5c0f\u8133\u9846\u7c92\u7d30\u80de\u30b7\u30ca\u30d7\u30b9\u306b\u304a\u3051\u308bNMDA\u53d7\u5bb9\u4f53\u306e\u5c40\u5728\u6a5f\u69cb\u306e\u89e3\u6790"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T16:17:52.277558+00:00"}