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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第116巻第7号

ストレプトゾトシン誘発糖尿病ラットにおけるPlasminogen Activator Inhibitor type 1 (PAI-1) とTissue Plasminogen Activator (t-PA) の発現制御 : 全身分布と腎臓における局在

http://hdl.handle.net/10191/2557
http://hdl.handle.net/10191/2557
8631574e-699e-41da-8263-c31a883825c9
名前 / ファイル ライセンス アクション
KJ00000141919.pdf KJ00000141919.pdf (1.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル ストレプトゾトシン誘発糖尿病ラットにおけるPlasminogen Activator Inhibitor type 1 (PAI-1) とTissue Plasminogen Activator (t-PA) の発現制御 : 全身分布と腎臓における局在
タイトル
言語 en
タイトル ストレプトゾトシン誘発糖尿病ラットにおけるPlasminogen Activator Inhibitor type 1 (PAI-1) とTissue Plasminogen Activator (t-PA) の発現制御 : 全身分布と腎臓における局在
言語
言語 jpn
キーワード
主題Scheme Other
主題 PAI-1
キーワード
主題Scheme Other
主題 t-PA
キーワード
主題Scheme Other
主題 STZ-induced diabetic rats
キーワード
主題Scheme Other
主題 kidney
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Regulation of Plasminogen Activator Inhibitor type1 (PAI-1) and Tissue Plasminogen Activator (t-PA) Expression in Streptozotocin-induced Diabetic Rats: Expression in Systemic Organs and Localization in the Kidney
著者 上村, 宗

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WEKO 92623

上村, 宗

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抄録
内容記述タイプ Abstract
内容記述 Expression of mRNAs for plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (t-PA) was examined in systemic organs of normal and streptozotocin (STZ)-induced diabetic rats by using RNase protection assay. PAI-1 mRNA was expressed in the whole eye, lung, myocardium, aorta, and kidney in normal rats while it was not detected or under detection level in the whole brain, liver and skeletal muscle. In diabetic rats, the level of PAI-1 mRNA increased in all the organs expressing PAI-1 mRNA except for the kidney. t-PA mRNA was expressed in the whole brain, whole eye, lung, myocardium, and kidney and, in diabetic rats, its level was found to be increased except for that in the kidney. The expression pattern in systemic organs of normal rats and its change in diabetic rats was quite similar between PAI-1 and t-PA mRNAs, suggesting their implications in the development of microangiopathy characteristic of diabetes mellitus. PAI-1 and t-PA mRNA expression in the kidney was found to be highly enriched in the glomeruli of both normal and diabetic rats. Double immunofluorescence staining with monoclonal antibody (mAb 5-1-6) against slit diaphragm revealed the co-localization of anti-PAI-1 antibody and mAb 5-1-6. These results suggests that the glomerular epithelial cells is the major cells in producing PAI-1 in the kidney.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 116, 号 7, p. 306-316, 発行日 2002-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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