{"created":"2021-03-01T06:17:57.823914+00:00","id":13599,"links":{},"metadata":{"_buckets":{"deposit":"36543cf2-a695-4b0b-8179-2acfa30b9f09"},"_deposit":{"id":"13599","owners":[],"pid":{"revision_id":0,"type":"depid","value":"13599"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00013599","sets":["453:456","471:537:538:1047"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Fenofibrate Inhibits Reactive Amyloidosis in Mice"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"501","bibliographicPageStart":"497","bibliographicVolumeNumber":"117","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2次性アミロイドーシスは関節リウマチを始めとした慢性炎症疾患に続発し,予後を左右しうる重要な合併症の一つである.一方,高脂血症治療薬として広く使われているフィブラート系薬剤は,近年その抗炎症作用が注目されている.今回,我々は,フェノフィブラートの2次性(炎症性)のアミロイド沈着及びその前駆物質である血清アミロイドA(SAA)に対する影響をマウスモデルを用い検討した.その結果,フェノフィブラートは容量依存性に臓器アミロイド沈着及び血中SAA濃度を抑制し,さらに,in vitroにおいて,単球からの炎症サイトカインの産生及び肝細胞からのSAA産生のいずれをも抑制した.フェノフィブラートは2次性アミロイドーシスの予防だけでなく,広く炎症制御に関わる可能性が示唆された.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村井, 丈寛"}],"nameIdentifiers":[{"nameIdentifier":"89349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒井, 勝光"}],"nameIdentifiers":[{"nameIdentifier":"89350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生越, 章"}],"nameIdentifiers":[{"nameIdentifier":"89351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽生, 忠正"}],"nameIdentifiers":[{"nameIdentifier":"89352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三井田, 孝"}],"nameIdentifiers":[{"nameIdentifier":"89353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 俊幸"}],"nameIdentifiers":[{"nameIdentifier":"89354","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"KJ00000142667.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000142667.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/13599/files/KJ00000142667.pdf"},"version_id":"9c4aac1f-b658-4f1d-a0d7-e97a217e7a96"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"2次性アミロイドーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"血清アミロイドA","subitem_subject_scheme":"Other"},{"subitem_subject":"フェノフィブラート","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性サイトカイン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"4-(1) フェノフィブラートによる2次性アミロイドーシスの抑制(シンポジウム 関節リウマチの診療 : 最近の進歩)(第584回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"4-(1) フェノフィブラートによる2次性アミロイドーシスの抑制(シンポジウム 関節リウマチの診療 : 最近の進歩)(第584回新潟医学会)"},{"subitem_title":"4-(1) フェノフィブラートによる2次性アミロイドーシスの抑制(シンポジウム 関節リウマチの診療 : 最近の進歩)(第584回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1047"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"13599","relation_version_is_last":true,"title":["4-(1) フェノフィブラートによる2次性アミロイドーシスの抑制(シンポジウム 関節リウマチの診療 : 最近の進歩)(第584回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:46:01.886295+00:00"}