{"created":"2021-03-01T06:17:08.027587+00:00","id":12827,"links":{},"metadata":{"_buckets":{"deposit":"94c46a0b-3dd8-4168-9fd6-304c4aafcaf1"},"_deposit":{"id":"12827","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12827"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012827","sets":["453:456","471:537:538:1033"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"BCG Induced Hepatic Granuloma Formation in TACO Transgenic Mice"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"621","bibliographicPageStart":"611","bibliographicVolumeNumber":"118","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"TACO(Tryptophane asoartate-containing coat protein)はBCG生菌を貪食したマクロファージの貪食空腹(phagosome)から単離された蛋白で,その膜周囲にとどまり続けてBCGのライソゾーム(lysosome)への移行を妨げ,結核菌の細胎内寄生成立に加担する分子と考えられている.本研究ではTACO過剰発現マウス(TG)を作製し,そのBCG感染時の肝臓における肉芽腫形成およびBCG菌数の推移を野生型マウス(WT)と比較し,TACOの結核菌貪食および殺菌における役割を検討した.TGにおいては感染早期(2週目まで)の肝肉芽腫数がWTに比較して有意に少なく,反対に4週目以後ではより増加した.肉芽腫内の類上皮細胞数はTGで多く,反対にTリンパ球数は少なかった.BCG静注1時間後の肝内のBCG貪食Kupffer細胞数はTGにおいて有意に少なく,BCG菌数も同様に少なかった.TGの腹腔滲出マクロファージはWTに比し有意にBCG貪食能が低く,その後の細胎内殺菌能も低い傾向がみられた.以上の成績からTACOは結核菌の殺菌のみならず,貪食機構にも関与する分子と考えられた.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"廣瀬, 貴之"}],"nameIdentifiers":[{"nameIdentifier":"85132","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"KJ00004300783.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004300783.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/12827/files/KJ00004300783.pdf"},"version_id":"bd35a31e-4ec4-48a8-a291-44a2dfd19ade"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TACO","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスジェニックマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"BCG","subitem_subject_scheme":"Other"},{"subitem_subject":"Kupffer細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"肉芽腫","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"TACO過剰発現マウスにおけるBCG誘発肝肉芽腫形成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TACO過剰発現マウスにおけるBCG誘発肝肉芽腫形成"},{"subitem_title":"TACO過剰発現マウスにおけるBCG誘発肝肉芽腫形成","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1033"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"12827","relation_version_is_last":true,"title":["TACO過剰発現マウスにおけるBCG誘発肝肉芽腫形成"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:45:32.159877+00:00"}