{"_buckets": {"deposit": "94c46a0b-3dd8-4168-9fd6-304c4aafcaf1"}, "_deposit": {"id": "12827", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "12827"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00012827", "sets": ["456", "1033"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "BCG Induced Hepatic Granuloma Formation in TACO Transgenic Mice"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "621", "bibliographicPageStart": "611", "bibliographicVolumeNumber": "118", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "TACO(Tryptophane asoartate-containing coat protein)はBCG生菌を貪食したマクロファージの貪食空腹(phagosome)から単離された蛋白で,その膜周囲にとどまり続けてBCGのライソゾーム(lysosome)への移行を妨げ,結核菌の細胎内寄生成立に加担する分子と考えられている.本研究ではTACO過剰発現マウス(TG)を作製し,そのBCG感染時の肝臓における肉芽腫形成およびBCG菌数の推移を野生型マウス(WT)と比較し,TACOの結核菌貪食および殺菌における役割を検討した.TGにおいては感染早期(2週目まで)の肝肉芽腫数がWTに比較して有意に少なく,反対に4週目以後ではより増加した.肉芽腫内の類上皮細胞数はTGで多く,反対にTリンパ球数は少なかった.BCG静注1時間後の肝内のBCG貪食Kupffer細胞数はTGにおいて有意に少なく,BCG菌数も同様に少なかった.TGの腹腔滲出マクロファージはWTに比し有意にBCG貪食能が低く,その後の細胎内殺菌能も低い傾向がみられた.以上の成績からTACOは結核菌の殺菌のみならず,貪食機構にも関与する分子と考えられた.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "廣瀬, 貴之"}], "nameIdentifiers": [{"nameIdentifier": "85132", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004300783.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "KJ00004300783.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/12827/files/KJ00004300783.pdf"}, "version_id": "bd35a31e-4ec4-48a8-a291-44a2dfd19ade"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "TACO", "subitem_subject_scheme": "Other"}, {"subitem_subject": "トランスジェニックマウス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BCG", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Kupffer細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "肉芽腫", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "TACO過剰発現マウスにおけるBCG誘発肝肉芽腫形成", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "TACO過剰発現マウスにおけるBCG誘発肝肉芽腫形成"}, {"subitem_title": "TACO過剰発現マウスにおけるBCG誘発肝肉芽腫形成", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1033"], "permalink_uri": "http://hdl.handle.net/10191/3125", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "12827", "relation": {}, "relation_version_is_last": true, "title": ["TACO過剰発現マウスにおけるBCG誘発肝肉芽腫形成"], "weko_shared_id": null}