{"created":"2021-03-01T06:16:50.293153+00:00","id":12555,"links":{},"metadata":{"_buckets":{"deposit":"1f7027a5-2571-4e66-a45a-652617ec7968"},"_deposit":{"id":"12555","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12555"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012555","sets":["453:456","471:537:538:1027"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Relationship between Conduction Delay in Right Ventricular Outflow Tract and Clinical Characterisics in Brugada Syndrome : Investigation of Signal Average Electrocardiogram and Electrophysiologic Study"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"293","bibliographicPageStart":"284","bibliographicVolumeNumber":"119","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"背景:Brugada症候群は,右側胸部誘導(V1-V3)において特徴的なST上昇を呈し,心室細動を特徴とする疾患である.心室細動の原因として右室流出路における心外膜側活動電位のdomeの減少によるphase 2 reentryが考えられているが未知の点が多い.目的:本研究において,我々はBrugada症候群症例の体表面加算平均心電図(SAECG)と電気生理学的検査(EPS)との関係を右室流出路(RVOT)に焦点をあて解析し,臨床的特徴との関係を検討した.方法:対象はBrugada症候群患者24例(男性23名,女性1名;平均61±16歳)である.症例を心停止群(7例),失神群(8例),無症状群(9例)に分け以下の指標を比較検討した.SAECGにおける遅延電位(LP)を既知の方法で検出し,右側胸部誘導(V1もしくはV2)と左側胸部誘導(V5もしくはV6)のfiltered QRS duration(それぞれRfQRSおよびLfQRS)を同様に加算平均から求め,誘導間の差を求めた.24例中18例では,SAECGを3回施行し,LPの再現性を検討した.電気生理学検査ではHV間隔と,RVOT刺激時におけるRVOTとRVA間の伝導時間(CT-OA)を測定し,心室内の伝導を評価した.結果:全例の60回のSAECGで,LPは14例で最低1回は陽性となり,7例で再現性を示した.その7例中5例(83%)は心停止群であった.心停止群のRfQRSとLfQRSとの差(RfQRS-LfQRS)は,失神群や無症状群よりも有意に長かった(29±1Ovs. 14±11(p<0.01)および7±5msec(p<0.001)).HV間隔は3群間で有意差はなかった(心停止群:53±11ms,失神群:52±7ms,無症状群:51±8ms).CT-OAはHV間隔と強い相関を示した(r=0.755,p=0.0003)が,CT-OAとRfQRS,RfQRS-LfQRSとは相間はみられなかった.植え込み型除細動器(ICD)は24例中20例で植え込まれた.平均37±15ヵ月の経過観察期間中に死亡例はなかったが,心停止群の1例で心室細動に対してICD治療が作動し洞調律に復した.結論:体表面加算平均心電図による,右側胸部誘導のQRS幅の延長は,Brugada症候群での不整脈事故の危険と関係があると考えられた.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"廣野, 崇"}],"nameIdentifiers":[{"nameIdentifier":"83700","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"KJ00004300197.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004300197.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/12555/files/KJ00004300197.pdf"},"version_id":"44c8a4bb-3208-4dd5-b53f-52571355abb2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Brugada症候群","subitem_subject_scheme":"Other"},{"subitem_subject":"体表面加算平均心電図","subitem_subject_scheme":"Other"},{"subitem_subject":"電気生理学検査","subitem_subject_scheme":"Other"},{"subitem_subject":"右室流出路","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Brugada症候群における右室流出路伝導遅延と臨床的特徴との関係 : 加算平均心電図と電気生理検査による検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Brugada症候群における右室流出路伝導遅延と臨床的特徴との関係 : 加算平均心電図と電気生理検査による検討"},{"subitem_title":"Brugada症候群における右室流出路伝導遅延と臨床的特徴との関係 : 加算平均心電図と電気生理検査による検討","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1027"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"12555","relation_version_is_last":true,"title":["Brugada症候群における右室流出路伝導遅延と臨床的特徴との関係 : 加算平均心電図と電気生理検査による検討"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:45:21.492103+00:00"}