{"created":"2021-03-01T06:16:47.648908+00:00","id":12514,"links":{},"metadata":{"_buckets":{"deposit":"da64bc21-27e5-43cd-a17f-4deb20e442c7"},"_deposit":{"id":"12514","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12514"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012514","sets":["453:456","471:537:538:1026"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Angiotensin II Receptor Blocker in Rats with Daunorubicin-induced Myocardial and Renal Disorders"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"335","bibliographicPageStart":"329","bibliographicVolumeNumber":"119","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アントラサイクリン系抗悪性腫瘍薬であるダウノルビシン(DNR)は白血病等の治療に多用されているが,時に心臓・腎臓障害を起こすことが知られている.一方,アンジオテンシン受容体拮抗薬(ARB)は主に高血圧患者に用いられているが,最近では腎臓病や心不全患者にも用いられ,その心・腎保護作用が注目されている.そこでDNR心筋障害ラットに対し,ARBのカンデサルタン・シレキセチルを投与し,心臓と腎臓の病理組織像,血行動態について検討した.正常群と比較し,DNR群では心機能の悪化及び腎糸球体・尿細管の障害が見られたが,カンデサルタン投与によりそれらが改善した.以上の結果よりカンデサルタンはDNR心腎障害を改善させると推測された.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"曽我, 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