{"created":"2021-03-01T06:16:46.509748+00:00","id":12496,"links":{},"metadata":{"_buckets":{"deposit":"b1434287-9d1e-47e6-ac89-2f68de845f7b"},"_deposit":{"id":"12496","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12496"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012496","sets":["453:456","471:537:538:1025"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"2 Serological Diagnosis of Patients with Hepatocellular Carcinoma (For the Eradication of Hepatocellular Carcinoma by the Avoidance of Development from Chronic Hepatitis to Hepatocellular Carcinoma)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"390","bibliographicPageStart":"385","bibliographicVolumeNumber":"119","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝細胞癌(HCC)にはアルファフェトプロテイン(AFP)とPIVKA-II(protein induced by vitamin Kabsence or antagonist-II),さらにAFP-L3分画(フコシル化AFP分画)という3種の腫瘍マーカーが存在する.第16回全国原発性肝癌追跡調査報告(2000-2001の全国集計)によれば,AFPならびにPIVKA-IIの陽性率はそれぞれ66%,62%と報告され,診断的価値が高いと考えられる.また,両者はTumorStageの進行に伴って上昇し,Stage Iでは52,31%よりStageの進行に伴い上昇し,Stage IVでは78,76%と高い陽性率を示している.基本的にAFP,PIVKA-IIは互いに相補的であり,両マーカーのcombination assayによりその診断能は向上する.また,両マーカーが陽性を示す際は,その濃度は互いに平行関係を示す場合が多いと考えられる.しかしながら,治療例においては両腫瘍マーカーに乖離が認められることがあり,その解釈に注意を要する.他方,AFPにおいては非特異的な上昇を認める場合があり,HCCの発生母地である肝硬変,慢性肝炎においても陽性を示す.これらの非特異的上昇との鑑別を目的にL3分画(フコース結合型AFP)が有用である.さらに,L3分画はHCCならびに良性肝疾患の鑑別以外にも,その生物学的悪性度を表すマーカーとしての意義が最近明らかになってきた.すなわち,これら3種のマーカーのHCCの診断,治療効果判定,再発時診断における意義を正しく理解し,HCCの予後改善に役立てることが重要と考えられる.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"見田, 有作"}],"nameIdentifiers":[{"nameIdentifier":"83420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青柳, 豊"}],"nameIdentifiers":[{"nameIdentifier":"83421","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"KJ00004300283.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004300283.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/12496/files/KJ00004300283.pdf"},"version_id":"73bed17e-bf55-417f-a344-2bf6a31dc8cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝細胞癌","subitem_subject_scheme":"Other"},{"subitem_subject":"AFP","subitem_subject_scheme":"Other"},{"subitem_subject":"PIVKA-II","subitem_subject_scheme":"Other"},{"subitem_subject":"L3","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2 肝細胞癌の血清学的診断(シンポジウム C型肝炎から肝癌へ,肝癌撲滅を目指して,第601回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2 肝細胞癌の血清学的診断(シンポジウム C型肝炎から肝癌へ,肝癌撲滅を目指して,第601回新潟医学会)"},{"subitem_title":"2 肝細胞癌の血清学的診断(シンポジウム C型肝炎から肝癌へ,肝癌撲滅を目指して,第601回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1025"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"12496","relation_version_is_last":true,"title":["2 肝細胞癌の血清学的診断(シンポジウム C型肝炎から肝癌へ,肝癌撲滅を目指して,第601回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:45:17.160683+00:00"}