{"created":"2021-03-01T06:16:17.774795+00:00","id":12047,"links":{},"metadata":{"_buckets":{"deposit":"eeeea2cc-f544-4a56-8844-1782f7e85670"},"_deposit":{"id":"12047","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12047"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012047","sets":["453:456","471:537:538:1013"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"PU.1 Expression Plays A Pivotal Role in Alveolar Macrophage Differentiation and Surfactant Catabolism in Newborn Rats"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"399","bibliographicPageStart":"389","bibliographicVolumeNumber":"120","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PU.1はマクロファージを含む骨髄球系細胞とBリンパ球の発生に不可欠な造血転写因子である.特発性肺胞蛋白症(idiopathic pulmonary alveolar proteinosis: IPAP)やgranulocyte macrophage colony stimulating factor(GM-CSF)欠損マウスの解析から,PU.1の発現が肺胞マクロファージの最終機能分化とサーファクタントの異化に重要であることが知られている.哺乳類においては生後ダイナミックに変化する呼吸環境の中で,サーファクタントの代謝と肺胞マクロファージの分化成熟にもPU.1は重要な役割を果たしていると考えられる.本研究では,生後のラット肺胞マクロファージおよび培養単球におけるPU.1の発現とサーファクタントの成分であるsurfactant protein B(SP-B)の代謝について検討した.生直後の肺胞マクロファージにはPU.1の発現はほとんど見られないが,生後1週間でPU.1陽性肺胞マクロファージは増加し,PU.1の発現も増強した.一方,生直後の肺胞マクロファージには多量のSP-Bの取り込みが見られ,1週後には減少した.成熟ラットの単球にPU.1の発現は見られないが,GMCSF存在下で培養すると日数の経過につれて形態的にマクロファージに分化し,PU.1の発現・増強が見られ,人工サーファクタント製剤の取り込みと分解が確認された.以上,生直後の肺胞マクロファージではPU.1の発現とSP-Bの異化は不十分で,生後1週間を境にPU.1の発現が増加し,SP-Bの異化能が亢進することが明らかにされた.これらの知見から新生児期のサーファクタント代謝における肺胞マクロファージの重要性が示された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"81122","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Iwabuchi, Haruko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩渕, 晴子"}],"nameIdentifiers":[{"nameIdentifier":"81121","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"21_0086.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"21_0086.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/12047/files/21_0086.pdf"},"version_id":"f7e1efe2-7a2c-4334-9d91-60d9b5357b35"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PU.1","subitem_subject_scheme":"Other"},{"subitem_subject":"サーファクタント","subitem_subject_scheme":"Other"},{"subitem_subject":"肺胞マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"取り込みと異化","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"出生後のラット肺胞マクロプアージにおけるPU.1の発現とサーファクタント代謝","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"出生後のラット肺胞マクロプアージにおけるPU.1の発現とサーファクタント代謝"},{"subitem_title":"出生後のラット肺胞マクロプアージにおけるPU.1の発現とサーファクタント代謝","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1013"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-04-08"},"publish_date":"2008-04-08","publish_status":"0","recid":"12047","relation_version_is_last":true,"title":["出生後のラット肺胞マクロプアージにおけるPU.1の発現とサーファクタント代謝"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:45:05.197671+00:00"}