{"created":"2021-03-01T06:16:14.769959+00:00","id":12000,"links":{},"metadata":{"_buckets":{"deposit":"e6cb8653-af7c-4f34-a4a1-287004dfcc20"},"_deposit":{"id":"12000","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12000"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012000","sets":["453:456","471:537:538:1011"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Mucin Core Protein Expression and p53 Protein Over Expression of Mucinous Carcinoma of the Colorectum"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"526","bibliographicPageStart":"518","bibliographicVolumeNumber":"120","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"一般に大腸粘液癌は,組織学的には細胞外粘液貯留(粘液結節:以下MC)が腫瘍全体の50%以上を占めるものと定義される.本研究は,外科切除MC随伴大癌76例,同MC非随伴大腸癌76例を対象として,癌の細胞分化(細胞粘液形質)と粘液癌では頻度が低いとされるp53蛋白過剰発現の面から,従来の粘液癌の定義の妥当性を検討した.対象例を腫瘍最大割面でMCが腫瘍全体に占める割合から[MC比>50%],[10≦MC比<50%],[0<MC比<10%],[MC比=0%]の4群に分け,それぞれのムチンコア蛋白MUC1,MUC2,MUC5ACの発現頻度とp53蛋白過剰発現頻度とを比較した.MCを随伴する大腸癌はその90%以上がMUC2を発現しており,それに対してMC非随伴大腸癌([MC比=0%]群)でMUC2を発現するものは10.5%のみであった.MC随伴癌は,MCの多寡によらず,3種類のムチンコア蛋白の発現状態(MUC phenotype)は同質であった.MC随伴癌のp53蛋白過剰発現は,MCの多寡に関わらず,非随伴癌に比べ有意に低く,MC随伴癌3群間では有意差はなかった.以上より,MCを随伴する大腸癌の中でMC比が50%を越えるもののみを粘液癌とする従来の定義には,妥当性は乏しいと考えられた.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"80870","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Niwa, Keiko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丹羽, 恵子"}],"nameIdentifiers":[{"nameIdentifier":"80869","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"110006483499.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110006483499.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/12000/files/110006483499.pdf"},"version_id":"3cd93a6a-0f2d-4fea-b0b3-b22175277ef4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸粘液癌","subitem_subject_scheme":"Other"},{"subitem_subject":"ムチンコア蛋白","subitem_subject_scheme":"Other"},{"subitem_subject":"p53蛋白過剰発現","subitem_subject_scheme":"Other"},{"subitem_subject":"MUC2","subitem_subject_scheme":"Other"},{"subitem_subject":"MUC1","subitem_subject_scheme":"Other"},{"subitem_subject":"MUC5AC","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ムチンコア蛋白発現,p53蛋白過剰発現からみた大腸粘液癌の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ムチンコア蛋白発現,p53蛋白過剰発現からみた大腸粘液癌の検討"},{"subitem_title":"ムチンコア蛋白発現,p53蛋白過剰発現からみた大腸粘液癌の検討","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1011"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-17"},"publish_date":"2012-10-17","publish_status":"0","recid":"12000","relation_version_is_last":true,"title":["ムチンコア蛋白発現,p53蛋白過剰発現からみた大腸粘液癌の検討"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T04:32:43.750806+00:00"}