{"_buckets": {"deposit": "e6cb8653-af7c-4f34-a4a1-287004dfcc20"}, "_deposit": {"id": "12000", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "12000"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00012000", "sets": ["456", "1011"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Mucin Core Protein Expression and p53 Protein Over Expression of Mucinous Carcinoma of the Colorectum"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "526", "bibliographicPageStart": "518", "bibliographicVolumeNumber": "120", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "一般に大腸粘液癌は,組織学的には細胞外粘液貯留(粘液結節:以下MC)が腫瘍全体の50%以上を占めるものと定義される.本研究は,外科切除MC随伴大癌76例,同MC非随伴大腸癌76例を対象として,癌の細胞分化(細胞粘液形質)と粘液癌では頻度が低いとされるp53蛋白過剰発現の面から,従来の粘液癌の定義の妥当性を検討した.対象例を腫瘍最大割面でMCが腫瘍全体に占める割合から[MC比\u003e50%],[10≦MC比\u003c50%],[0\u003cMC比\u003c10%],[MC比=0%]の4群に分け,それぞれのムチンコア蛋白MUC1,MUC2,MUC5ACの発現頻度とp53蛋白過剰発現頻度とを比較した.MCを随伴する大腸癌はその90%以上がMUC2を発現しており,それに対してMC非随伴大腸癌([MC比=0%]群)でMUC2を発現するものは10.5%のみであった.MC随伴癌は,MCの多寡によらず,3種類のムチンコア蛋白の発現状態(MUC phenotype)は同質であった.MC随伴癌のp53蛋白過剰発現は,MCの多寡に関わらず,非随伴癌に比べ有意に低く,MC随伴癌3群間では有意差はなかった.以上より,MCを随伴する大腸癌の中でMC比が50%を越えるもののみを粘液癌とする従来の定義には,妥当性は乏しいと考えられた.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "80870", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Niwa, Keiko"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "丹羽, 恵子"}], "nameIdentifiers": [{"nameIdentifier": "80869", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110006483499.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "110006483499.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/12000/files/110006483499.pdf"}, "version_id": "3cd93a6a-0f2d-4fea-b0b3-b22175277ef4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "大腸粘液癌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ムチンコア蛋白", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53蛋白過剰発現", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MUC2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MUC1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MUC5AC", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ムチンコア蛋白発現,p53蛋白過剰発現からみた大腸粘液癌の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ムチンコア蛋白発現,p53蛋白過剰発現からみた大腸粘液癌の検討"}, {"subitem_title": "ムチンコア蛋白発現,p53蛋白過剰発現からみた大腸粘液癌の検討", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1011"], "permalink_uri": "http://hdl.handle.net/10191/19911", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-10-17"}, "publish_date": "2012-10-17", "publish_status": "0", "recid": "12000", "relation": {}, "relation_version_is_last": true, "title": ["ムチンコア蛋白発現,p53蛋白過剰発現からみた大腸粘液癌の検討"], "weko_shared_id": null}