@article{oai:niigata-u.repo.nii.ac.jp:00011786,
 author = {清水, 不二雄},
 issue = {3},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Mar},
 note = {Masugi nephritis, induced by Masugi et al, demonstrated that immune reactions in glomeruli caused renal lesions. It was induced by injection of heterologous antiserum produced against whole kidney homogenates. In order to analyze the responsible immune reactions causing renal lesions, two methods were applied. The first one is the approach from the antigenic side, that is, the purification of antigen used for immunization and second one is from the antibody side, namely, the application of the advanced technology for monoclonal antibody (mAb) production. The group of the author succeeded in producing two kinds of proteinuria inducing mAbs, antithy-1 mAbl-22-3 and anti-rat nephrin mAb 5-1-6. Using the latter, we analyzed the proteinuria mechanism and suggested the importance of the slit diaphragm in keeping the normal glomerular permselectivity. Succeeding in cloning the rat homologues of podocin as well as of nephrin, we demonstrated that such slit diaphragm-associated molecules are intimately related to the acquired renal lesions too. Initiated by nephrin many new functional molecules associated with podocyte function have been reported and such a complex is regarded as playing the roles of signal transduction, essential for podocyte biological functions. These molecules are targets for trials to prevent the proteinuria resulting in the amelioration of the progression of renal lesions to the irreversible renal insufficiency.},
 pages = {123--127},
 title = {腎不全への進展阻止を目指して : ラットとともに40年(最終講義)},
 volume = {121},
 year = {2007}
}