{"created":"2021-03-01T06:15:47.303666+00:00","id":11576,"links":{},"metadata":{"_buckets":{"deposit":"705d987d-ace6-44b6-b1bb-4cc1e164502e"},"_deposit":{"id":"11576","owners":[],"pid":{"revision_id":0,"type":"depid","value":"11576"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00011576","sets":["453:456","471:537:538:1001"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Cyclosporine Concentration for Preventing Acute GVHD after Allogeneic Hematopoietic Stem Cell Transplantation"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"403","bibliographicPageStart":"394","bibliographicVolumeNumber":"121","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"造血幹細胞移植におけるgradeII-IV急性GVHD発症の危険因子を同定するために,1989年3月から2001年7月までに当院で施行された造血幹細胞移植症例のデータを後方視的に解析した.CyclosporinA(CsA)と短期Methotrexate(MTX)の併用でGVHD予防を行った症例は,73例(男性47例,女性26例)であった.CsAは1.5mg/kgの用量とし3時間点滴静注1日2回行い,移植day-1から開始して,前処置による腸管障害が改善して経口可能になるまで継続した.MTXは15mg/m^2をday1,10mg/m^2をday3,6そして11に投与した.GradeII-IV急性GVHDは18症例(25%)に発症した.多変量COX回帰解析によると,C5(静注開始5時間後の全血血中濃度)が高値であることがgradeII-IV急性GVHD発症を抑制して,1ng/mLの上昇につき,ハザード比0.994(95%信頼区間0.989-0.999)で抑制したことを明らかにした.今回の解析結果は,CsA血中濃度のきめ細かなモニターリングが,重症急性GVHD発症の予防に有効である可能性を示唆している.今後これを確認するためには,さらに前方視的臨床研究が必要である.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"78457","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Izumi, Noriko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_relation_31":{"attribute_name":"異版である","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110007146231","subitem_relation_type_select":"URI"}}]},"item_7_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和泉, 典子"}],"nameIdentifiers":[{"nameIdentifier":"78456","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"110007146231.pdf","filesize":[{"value":"677.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110007146231.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/11576/files/110007146231.pdf"},"version_id":"13e63c8f-0ef5-44db-a768-18380fa3f48f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"同種造血幹細胞移植","subitem_subject_scheme":"Other"},{"subitem_subject":"GVHD","subitem_subject_scheme":"Other"},{"subitem_subject":"シクロスポリン血中濃度","subitem_subject_scheme":"Other"},{"subitem_subject":"予防","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"同種造血幹細胞移植における急性GVHD発症に対するシクロスポリン濃度測定の意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"同種造血幹細胞移植における急性GVHD発症に対するシクロスポリン濃度測定の意義"},{"subitem_title":"同種造血幹細胞移植における急性GVHD発症に対するシクロスポリン濃度測定の意義","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1001"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-04"},"publish_date":"2015-08-04","publish_status":"0","recid":"11576","relation_version_is_last":true,"title":["同種造血幹細胞移植における急性GVHD発症に対するシクロスポリン濃度測定の意義"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:50.738499+00:00"}