{"created":"2021-03-01T06:15:46.087549+00:00","id":11557,"links":{},"metadata":{"_buckets":{"deposit":"fe584a0d-870c-4a1b-a9dc-fe0d85fad5f3"},"_deposit":{"id":"11557","owners":[],"pid":{"revision_id":0,"type":"depid","value":"11557"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00011557","sets":["453:456","471:537:538:1000"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Applications of Advanced Spectroscopy in Medical Pharmacy"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"431","bibliographicPageStart":"427","bibliographicVolumeNumber":"121","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"薬物の作用機序を原理的に理解するには,薬物との相互作用に伴う標的生体分子の構造・機能の変化を知る必要がある.このような研究はX線結晶解析や高分解能NMRを用いて行われているが,近年の光発生・検出技術の進歩に伴い,分光学的手法も有力な研究手段となりつつある.中でも共鳴ラマン分光法は,水溶液中で測定が可能であり,固体・溶液にかかわらず測定でき,空間・時間分解能が高く,高選択であるという特徴を持つ.本稿では,ラマン分光法と共鳴ラマン効果について概説した後,共鳴一差ラマン分光による1残基構造変化検出,マイクロ流動チップー顕微ラマン分光による赤血球の脱酸素過程の解析など,ラマン分光法を薬学領域に応用した研究例を紹介する.また,分子分光法は基本的には非破壊計測であり,この特徴を生かしてin situ分析への応用も広がっている.薬剤部業務にin situ分析を応用した例として,テラヘルツ波を用いた薬剤識別装置開発の試みについても述べる.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"78385","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Toyama, Akira"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_relation_31":{"attribute_name":"異版である","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110007146432","subitem_relation_type_select":"URI"}}]},"item_7_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"外山, 聡"}],"nameIdentifiers":[{"nameIdentifier":"78384","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"110007146432.pdf","filesize":[{"value":"603.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110007146432.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/11557/files/110007146432.pdf"},"version_id":"2219d972-fc18-4b88-8cac-9b571a73c046"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ラマン分光法","subitem_subject_scheme":"Other"},{"subitem_subject":"テラヘルツ分光","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"最新の分光学的手法の医療薬学領域への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"最新の分光学的手法の医療薬学領域への応用"},{"subitem_title":"最新の分光学的手法の医療薬学領域への応用","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1000"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-04"},"publish_date":"2015-08-04","publish_status":"0","recid":"11557","relation_version_is_last":true,"title":["最新の分光学的手法の医療薬学領域への応用"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:49.910831+00:00"}