{"created":"2021-03-01T06:15:27.173601+00:00","id":11259,"links":{},"metadata":{"_buckets":{"deposit":"700a2d96-87a1-4615-8582-dca6a31cc0e2"},"_deposit":{"id":"11259","owners":[],"pid":{"revision_id":0,"type":"depid","value":"11259"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00011259","sets":["453:456","471:537:538:992"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Erythropoietin Administration was Effective for the Treatment of Monocrotaline : Induced Pulmonary Hypertension in Rats"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"193","bibliographicPageStart":"184","bibliographicVolumeNumber":"122","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"エリスロポエチン(EPO)は赤血球造血因子として発見され,腎性貧血の治療に用いられてきた(エンドクリン系).EPO受容体は赤血球系造血細胞のみならず心血管系や中枢神経にも発現しており,組織保護作用・血管新生作用などを介した多彩なパラクリン系をもつことが知られるようになった.原発性および二次性の肺高血圧症(PH)は予後不良の疾患で,肺血管内皮障害が発症と進展に重要とされる.EPOの投与が肺血管内皮の生存を高めることでPHを改善しうると考え,動物モデルを用いた治療実験をおこなった.ラットにモノクロタリンを投与すると,肺細動脈の血管内皮障害と中膜肥厚によるPHが誘発された.これをEPO持続静注で治療したところ,抗アポトーシス分子BCL-XLの誘導と血管内皮由来分子PECAM-1およびエンドセリンの発現量の減少の抑制,肺細動脈の中膜肥厚の改善,および肺高血圧と右心肥大の改善が観察された.EPOのアシアロ体にはこの作用がなかった.肺高血圧の治療にEPO投与が有効である可能性が示された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"76655","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ikarashi, Noboru"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五十嵐, 登"}],"nameIdentifiers":[{"nameIdentifier":"76654","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"110007146315.pdf","filesize":[{"value":"834.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110007146315.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/11259/files/110007146315.pdf"},"version_id":"ef5f08f8-54ee-4c99-9cda-dbb729bae7d2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"モノクロタリン","subitem_subject_scheme":"Other"},{"subitem_subject":"アシアロエリスロポエチン","subitem_subject_scheme":"Other"},{"subitem_subject":"血管","subitem_subject_scheme":"Other"},{"subitem_subject":"内皮障害","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラットのモノクロタリン誘発による実験的肺高血圧症モデルに対するエリスロポエチン投与の有効性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラットのモノクロタリン誘発による実験的肺高血圧症モデルに対するエリスロポエチン投与の有効性"},{"subitem_title":"ラットのモノクロタリン誘発による実験的肺高血圧症モデルに対するエリスロポエチン投与の有効性","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","992"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-28"},"publish_date":"2012-09-28","publish_status":"0","recid":"11259","relation_version_is_last":true,"title":["ラットのモノクロタリン誘発による実験的肺高血圧症モデルに対するエリスロポエチン投与の有効性"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:41.683498+00:00"}