{"created":"2021-03-01T06:15:24.829329+00:00","id":11222,"links":{},"metadata":{"_buckets":{"deposit":"d1a8b40a-7add-4a01-8e1e-bdc4200d806a"},"_deposit":{"id":"11222","owners":[],"pid":{"revision_id":0,"type":"depid","value":"11222"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00011222","sets":["453:456","471:537:538:991"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Properties of Multistage Case - Control Association Study Designs Based on SNP Data for Identifying Disease Susceptibility Genes"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"261","bibliographicPageStart":"251","bibliographicVolumeNumber":"122","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A multistage case-control association study is one of the study designs to efficiently identify disease susceptibility genes. The purpose of this study was to clarify the properties of multistage case - control association studies. For this purpose, new programs for n-stage designs (n being an arbitrary integer larger than 1) were developed to calculate statistical powers, positive predictive values (PPVs) and numbers of genotypings of replication - based analysis (RBA) and joint analysis (JA) . Assuming that the numbers of alleles remaining at the final stage or the numbers of genotypings were fixed, the powers and PPVs of RBA and JA in three - stage designs were higher than those indicators in two - stage designs when a proportion of the sample size at the 1st stage (π_<s,1>) was smaller than 0.5. On the other hand, when π_<s,1> j was larger than 0.5, the indicators in the two - stage designs were higher than those in the three - stage designs. This tendency was more remarkable the closer the proportions of sample sizes of the 2nd and 3rd stages were and was more remarkable in JA than in RBA. It may be useful to conduct a prior simulation under various conditions by our programs for multistage designs at the planning stage of a genome - wide association study.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"76425","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kitamura, Nobutaka"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北村, 信隆"}],"nameIdentifiers":[{"nameIdentifier":"76424","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"110007146345.pdf","filesize":[{"value":"885.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110007146345.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/11222/files/110007146345.pdf"},"version_id":"3e2500cb-2e54-4101-bede-4292894b1422"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"case - control association study","subitem_subject_scheme":"Other"},{"subitem_subject":"multistage design","subitem_subject_scheme":"Other"},{"subitem_subject":"single nucleotide polymor - phisms (SNPs)","subitem_subject_scheme":"Other"},{"subitem_subject":"replication - based analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"joint analysis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SNPデータに基づく疾患感受性遺伝子同定のための多段階症例 : 対照研究デザインの特性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SNPデータに基づく疾患感受性遺伝子同定のための多段階症例 : 対照研究デザインの特性"},{"subitem_title":"SNPデータに基づく疾患感受性遺伝子同定のための多段階症例 : 対照研究デザインの特性","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","991"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-27"},"publish_date":"2012-09-27","publish_status":"0","recid":"11222","relation_version_is_last":true,"title":["SNPデータに基づく疾患感受性遺伝子同定のための多段階症例 : 対照研究デザインの特性"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:38.256997+00:00"}