{"created":"2021-03-01T06:15:07.221062+00:00","id":10948,"links":{},"metadata":{"_buckets":{"deposit":"05218217-ea2f-457f-b117-5b68f9c83553"},"_deposit":{"id":"10948","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10948"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010948","sets":["453:456","471:537:538:985"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Immunohistochemical Study for Isolated Tumor Cell (ITC) of Lymph Node in Intramucosal Colorectal Carcinoma"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"625","bibliographicPageStart":"619","bibliographicVolumeNumber":"122","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸粘膜内癌にはリンパ節転移例の報告はなく, 大腸粘膜内癌にはリンパ節転移能がないと考えられてきた. しかし従来の大腸粘膜内癌リンパ節転移に関する検索は, HE染色標本のみを元に行われたものであり, 免疫組織学的に同定されるりンパ節微小転移(isolated tumor cell: ITC)の有無については検討されていない. 本研究は, リンパ節郭清を伴う外科切除が施行され, 病変の全割切片による組織学的検索が行われた大腸粘膜内癌36例を対象に, 上皮性サイトケラチンCAM5.2免疫染色によりリンパ節ITCを検索し, ITCと原発巣粘膜内癌の組織学的因子との関連を検討した. 原発巣大腸粘膜内癌は全例が分化型(高分化･中分化)腺癌で, リンパ管侵襲･静脈侵襲, 蔟出のリンパ節転移リスク因子は陰性であり, 対象とした557個のリンパ節全てにITCは認められなかった. 以上のことから, 大腸粘膜内癌では免疫組織学的に同定されるITCすら存在せず, リンパ節転移能のない癌である可能性が高いことが再確認された. 大腸粘膜内癌では, 原発巣にリンパ節転移形成過程の第一段階である蔟出形成がなく, そのことがリンパ節転移が生じない主要因として推定された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"74608","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Matsuzawa, Takeaki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松澤, 岳晃"}],"nameIdentifiers":[{"nameIdentifier":"74607","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"122(11)_619-625.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"122(11)_619-625.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10948/files/122(11)_619-625.pdf"},"version_id":"a100d41c-774b-4056-94e0-2c9b52a8ee98"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸粘膜内癌","subitem_subject_scheme":"Other"},{"subitem_subject":"ITC","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ節転移","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫染色","subitem_subject_scheme":"Other"},{"subitem_subject":"蔟出","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"大腸粘膜内癌のリンパ節ITC(isolsted tumor cell)の免疫組織学的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸粘膜内癌のリンパ節ITC(isolsted tumor cell)の免疫組織学的検討"},{"subitem_title":"大腸粘膜内癌のリンパ節ITC(isolsted tumor cell)の免疫組織学的検討","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","985"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-18"},"publish_date":"2014-07-18","publish_status":"0","recid":"10948","relation_version_is_last":true,"title":["大腸粘膜内癌のリンパ節ITC(isolsted tumor cell)の免疫組織学的検討"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:29.121030+00:00"}