{"created":"2021-03-01T06:14:39.581545+00:00","id":10516,"links":{},"metadata":{"_buckets":{"deposit":"a77354ad-2126-448e-bf01-2fffd6ddb3f8"},"_deposit":{"id":"10516","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10516"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010516"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"My Academic Research on Dialysis-related Amyloidosis"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"604","bibliographicPageStart":"599","bibliographicVolumeNumber":"123","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"My academic and research career on dialysis-related amyloidosis was described in the final lecture as my professor retirement from the Department of Internal Medicine II. Dialysis-related amyloidosis has been becoming a frequent and serious complication in patients on long-term hemodialysis around 1980\uff5e1985. We have identified \u03b2_2-microglobulin (\u03b2_2-m) biochemically as the major protein constituent of the amyloid fibrils in 1985. Since \u03b2_2-m is a major structural component of this type of amyloidosis, serum \u03b2_2-m is thought to be a precursor protein. A negative correlation has been demonstrated between serum \u03b2_2-m concentration and glomerular filtration rate in chronic renal failure peatients. After the start of hemodialysis, serum \u03b2_2-m concentrations show a rapid increase and become markedly elevated, exceeding the upper limit of normal by 40 times or more. This indicates that removal of \u03b2_2-m from the blood is an important therapeutic approach to this form of amyloidosis. Clinical therapeutic strategies for dialysis-related amyloidosis have attempted to remove \u03b2_2-m from the serum by using high-flux membrane dialyzers. We have investigated the clinical efficacy of direct hemoperfusion with a \u03b2_2-m adsorption column in the patients with dialysis-related amyloidosis. Finally, we have demonstrated the column is useful for preventing progression of dialysis-related amyloidosis and in ameliorating or arresting symptoms of this disorder. It will be helpful to establish more effective prevention and therapy in the future.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"72017","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Gejyo, Fumitake"}]}]},"item_7_publisher_7":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"\u65b0\u6f5f\u533b\u5b66\u4f1a"}]},"item_7_select_19":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"\u4e0b\u6761, \u6587\u6b66"}],"nameIdentifiers":[{"nameIdentifier":"72016","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"123(12)_599-604.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"123(12)_599-604.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10516/files/123(12)_599-604.pdf"},"version_id":"93b10131-9f33-4f3f-bcf1-a03f2c22d9ca"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"\u9577\u671f\u8840\u6db2\u900f\u6790","subitem_subject_scheme":"Other"},{"subitem_subject":"\u900f\u6790\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9","subitem_subject_scheme":"Other"},{"subitem_subject":"\u03b2_2-\u30df\u30af\u30ed\u30b0\u30ed\u30d6\u30ea\u30f3","subitem_subject_scheme":"Other"},{"subitem_subject":"\u5438\u7740\u30ab\u30e9\u30e0","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"\u6700\u7d42\u8b1b\u7fa9 : \u6211\u304c\u5b66\u554f : \u900f\u6790\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u306e\u7814\u7a76\u3068\u5171\u306b","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"\u6700\u7d42\u8b1b\u7fa9 : \u6211\u304c\u5b66\u554f : \u900f\u6790\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u306e\u7814\u7a76\u3068\u5171\u306b"},{"subitem_title":"\u6700\u7d42\u8b1b\u7fa9 : \u6211\u304c\u5b66\u554f : \u900f\u6790\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u306e\u7814\u7a76\u3068\u5171\u306b","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["453/456","471/537/538/972"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2014-07-22"},"publish_date":"2014-07-22","publish_status":"0","recid":"10516","relation_version_is_last":true,"title":["\u6700\u7d42\u8b1b\u7fa9 : \u6211\u304c\u5b66\u554f : \u900f\u6790\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u306e\u7814\u7a76\u3068\u5171\u306b"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T17:55:03.270856+00:00"}