{"created":"2021-03-01T06:14:39.581545+00:00","id":10516,"links":{},"metadata":{"_buckets":{"deposit":"a77354ad-2126-448e-bf01-2fffd6ddb3f8"},"_deposit":{"id":"10516","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10516"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010516","sets":["453:456","471:537:538:972"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"My Academic Research on Dialysis-related Amyloidosis"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"604","bibliographicPageStart":"599","bibliographicVolumeNumber":"123","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"My academic and research career on dialysis-related amyloidosis was described in the final lecture as my professor retirement from the Department of Internal Medicine II. Dialysis-related amyloidosis has been becoming a frequent and serious complication in patients on long-term hemodialysis around 1980～1985. We have identified β_2-microglobulin (β_2-m) biochemically as the major protein constituent of the amyloid fibrils in 1985. Since β_2-m is a major structural component of this type of amyloidosis, serum β_2-m is thought to be a precursor protein. A negative correlation has been demonstrated between serum β_2-m concentration and glomerular filtration rate in chronic renal failure peatients. After the start of hemodialysis, serum β_2-m concentrations show a rapid increase and become markedly elevated, exceeding the upper limit of normal by 40 times or more. This indicates that removal of β_2-m from the blood is an important therapeutic approach to this form of amyloidosis. Clinical therapeutic strategies for dialysis-related amyloidosis have attempted to remove β_2-m from the serum by using high-flux membrane dialyzers. We have investigated the clinical efficacy of direct hemoperfusion with a β_2-m adsorption column in the patients with dialysis-related amyloidosis. Finally, we have demonstrated the column is useful for preventing progression of dialysis-related amyloidosis and in ameliorating or arresting symptoms of this disorder. It will be helpful to establish more effective prevention and therapy in the future.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"72017","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Gejyo, Fumitake"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下条, 文武"}],"nameIdentifiers":[{"nameIdentifier":"72016","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"123(12)_599-604.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"123(12)_599-604.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10516/files/123(12)_599-604.pdf"},"version_id":"93b10131-9f33-4f3f-bcf1-a03f2c22d9ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"長期血液透析","subitem_subject_scheme":"Other"},{"subitem_subject":"透析アミロイドーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"β_2-ミクログロブリン","subitem_subject_scheme":"Other"},{"subitem_subject":"吸着カラム","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に"},{"subitem_title":"最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","972"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-22"},"publish_date":"2014-07-22","publish_status":"0","recid":"10516","relation_version_is_last":true,"title":["最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:10.539247+00:00"}