{"_buckets": {"deposit": "a77354ad-2126-448e-bf01-2fffd6ddb3f8"}, "_deposit": {"id": "10516", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10516"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00010516", "sets": ["456", "972"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "My Academic Research on Dialysis-related Amyloidosis"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "604", "bibliographicPageStart": "599", "bibliographicVolumeNumber": "123", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "My academic and research career on dialysis-related amyloidosis was described in the final lecture as my professor retirement from the Department of Internal Medicine II. Dialysis-related amyloidosis has been becoming a frequent and serious complication in patients on long-term hemodialysis around 1980～1985. We have identified β_2-microglobulin (β_2-m) biochemically as the major protein constituent of the amyloid fibrils in 1985. Since β_2-m is a major structural component of this type of amyloidosis, serum β_2-m is thought to be a precursor protein. A negative correlation has been demonstrated between serum β_2-m concentration and glomerular filtration rate in chronic renal failure peatients. After the start of hemodialysis, serum β_2-m concentrations show a rapid increase and become markedly elevated, exceeding the upper limit of normal by 40 times or more. This indicates that removal of β_2-m from the blood is an important therapeutic approach to this form of amyloidosis. Clinical therapeutic strategies for dialysis-related amyloidosis have attempted to remove β_2-m from the serum by using high-flux membrane dialyzers. We have investigated the clinical efficacy of direct hemoperfusion with a β_2-m adsorption column in the patients with dialysis-related amyloidosis. Finally, we have demonstrated the column is useful for preventing progression of dialysis-related amyloidosis and in ameliorating or arresting symptoms of this disorder. It will be helpful to establish more effective prevention and therapy in the future.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "72017", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Gejyo, Fumitake"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "下条, 文武"}], "nameIdentifiers": [{"nameIdentifier": "72016", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "123(12)_599-604.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "123(12)_599-604.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/10516/files/123(12)_599-604.pdf"}, "version_id": "93b10131-9f33-4f3f-bcf1-a03f2c22d9ca"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "長期血液透析", "subitem_subject_scheme": "Other"}, {"subitem_subject": "透析アミロイドーシス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "β_2-ミクログロブリン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "吸着カラム", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に"}, {"subitem_title": "最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "972"], "permalink_uri": "http://hdl.handle.net/10191/28571", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-07-22"}, "publish_date": "2014-07-22", "publish_status": "0", "recid": "10516", "relation": {}, "relation_version_is_last": true, "title": ["最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に"], "weko_shared_id": null}