{"created":"2021-03-01T06:14:38.634652+00:00","id":10501,"links":{},"metadata":{"_buckets":{"deposit":"64670ac7-322f-461f-851f-abc3d5cff257"},"_deposit":{"id":"10501","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10501"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010501","sets":["453:456","471:537:538:971"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Selective Loss of Hepatic NKT Cells in Chronic Liver Injury in Mice"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"37","bibliographicPageStart":"29","bibliographicVolumeNumber":"124","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生体の中でNKT細胞が最も多く存在する臓器は肝臓である. マウス実験モデルにおいて, 急性肝障害の病態形成にNKT細胞が関与していることが明らかになってきた. しかし, 慢性の肝障害において, NKT細胞がどのように変化し, またその病態にどのように関与しているかは明らかでない. 本研究では, マウスに四塩化炭素を投与して慢性の肝障害・肝硬変を発症させ, その発症過程および回復過程でのNKT細胞の解析を行った. 四塩化炭素により肝硬変が誘導される過程において, 肝NKT細胞の選択的な減少とともに肝細胞上のCD1dの発現低下が見られた. 四塩化炭素投与中止により, 肝硬変から回復する過程では, 減少していた肝NKT細胞数は正常レベルまで回復し, 肝細胞上のCD1dの発現も正常レベルに戻った. 四塩化炭素によって肝細胞が傷害を受け, NKT細胞の分化・維持に必須の分子であるCD1d分子の肝細胞上での発現が低下し, その結果, 肝NⅨT細胞が選択的に減少することが示唆された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"71947","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kokai, Hidenaka"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小海, 秀央"}],"nameIdentifiers":[{"nameIdentifier":"71946","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"124(1)_29-37.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"124(1)_29-37.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10501/files/124(1)_29-37.pdf"},"version_id":"5804f5bb-7fbf-421e-a2ec-c6fabbbee53a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NKT細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性肝障害","subitem_subject_scheme":"Other"},{"subitem_subject":"肝硬変","subitem_subject_scheme":"Other"},{"subitem_subject":"CD1d","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"慢性肝障害における肝NKT細胞の動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性肝障害における肝NKT細胞の動態"},{"subitem_title":"慢性肝障害における肝NKT細胞の動態","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","971"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-24"},"publish_date":"2014-07-24","publish_status":"0","recid":"10501","relation_version_is_last":true,"title":["慢性肝障害における肝NKT細胞の動態"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:11.140987+00:00"}