{"_buckets": {"deposit": "64670ac7-322f-461f-851f-abc3d5cff257"}, "_deposit": {"id": "10501", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10501"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00010501", "sets": ["456", "971"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Selective Loss of Hepatic NKT Cells in Chronic Liver Injury in Mice"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "37", "bibliographicPageStart": "29", "bibliographicVolumeNumber": "124", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "生体の中でNKT細胞が最も多く存在する臓器は肝臓である. マウス実験モデルにおいて, 急性肝障害の病態形成にNKT細胞が関与していることが明らかになってきた. しかし, 慢性の肝障害において, NKT細胞がどのように変化し, またその病態にどのように関与しているかは明らかでない. 本研究では, マウスに四塩化炭素を投与して慢性の肝障害・肝硬変を発症させ, その発症過程および回復過程でのNKT細胞の解析を行った. 四塩化炭素により肝硬変が誘導される過程において, 肝NKT細胞の選択的な減少とともに肝細胞上のCD1dの発現低下が見られた. 四塩化炭素投与中止により, 肝硬変から回復する過程では, 減少していた肝NKT細胞数は正常レベルまで回復し, 肝細胞上のCD1dの発現も正常レベルに戻った. 四塩化炭素によって肝細胞が傷害を受け, NKT細胞の分化・維持に必須の分子であるCD1d分子の肝細胞上での発現が低下し, その結果, 肝NⅨT細胞が選択的に減少することが示唆された.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "71947", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kokai, Hidenaka"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小海, 秀央"}], "nameIdentifiers": [{"nameIdentifier": "71946", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "124(1)_29-37.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "124(1)_29-37.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/10501/files/124(1)_29-37.pdf"}, "version_id": "5804f5bb-7fbf-421e-a2ec-c6fabbbee53a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "NKT細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "慢性肝障害", "subitem_subject_scheme": "Other"}, {"subitem_subject": "肝硬変", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD1d", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "慢性肝障害における肝NKT細胞の動態", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "慢性肝障害における肝NKT細胞の動態"}, {"subitem_title": "慢性肝障害における肝NKT細胞の動態", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "971"], "permalink_uri": "http://hdl.handle.net/10191/28648", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-07-24"}, "publish_date": "2014-07-24", "publish_status": "0", "recid": "10501", "relation": {}, "relation_version_is_last": true, "title": ["慢性肝障害における肝NKT細胞の動態"], "weko_shared_id": null}