{"created":"2021-03-01T06:14:37.064810+00:00","id":10477,"links":{},"metadata":{"_buckets":{"deposit":"cd0ed172-cf84-4028-b56f-15bdfe7244c3"},"_deposit":{"id":"10477","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10477"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010477","sets":["453:456","471:537:538:970"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Rat IL-1 Receptor-Ig Heterodimer as a IL-1 Inhibitor"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"75","bibliographicPageStart":"65","bibliographicVolumeNumber":"124","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生物学的製剤は, 自己免疫疾患の治療に大きなパラダイムシフトを起こしつつあり, 他の疾患にもその有用性がいくつか報告されてきている. その中でも, IL-1は様々な炎症の中心的役割を担うサイトカインの一つであり, IL-1を阻害する生物学的製剤は, 幅広い疾患に有効性を示す可能性がある. 今回, 私は, IL-1受容体タイプII (IL-1RII) -IgFcとIL-1受容体アクセサリー蛋白 (IL-1Racp)-IgFcのヘテロダイマーを作成し, そのIL-1阻害作用を検討した. pCAGGSプラスミドベクターにIL-1RII-IgFcとIL-1Racp-IgFcをそれぞれ挿入したものを作成し, Cos7培養細胞に遺伝子導入して得られた培養上清を用いてIL-1阻害作用を検討した. IL-1阻害作用は, NRK49F培養細胞にIL-1αとそれぞれのCos7培養上清を添加し, そのMCP-1の遺伝子発現の変化を定量的RT-PCRで測定し, 判定した. IL-1阻害作用は, それぞれのホモダイマーではあまりみられず, ヘテロダイマーだけに非常に強いIL-1阻害作用がみられた. その作用は, 現在海外で市販されはじめたアナキンラの約10000倍強力であり, 新しい生物学的製剤として期待できると考えられた.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"71828","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Otaki, Keita"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大瀧, 啓太"}],"nameIdentifiers":[{"nameIdentifier":"71827","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"124(2)_65-75.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"124(2)_65-75.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10477/files/124(2)_65-75.pdf"},"version_id":"697620b7-db29-436c-83ff-2b7b5a42d3ac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"生物学的製剤","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-1阻害薬","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-1受容体へテロダイマー","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫疾患","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラットIL-1受容体-IgへテロダイマーによるIL-1阻害作用の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラットIL-1受容体-IgへテロダイマーによるIL-1阻害作用の検討"},{"subitem_title":"ラットIL-1受容体-IgへテロダイマーによるIL-1阻害作用の検討","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","970"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-24"},"publish_date":"2014-07-24","publish_status":"0","recid":"10477","relation_version_is_last":true,"title":["ラットIL-1受容体-IgへテロダイマーによるIL-1阻害作用の検討"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:09.924427+00:00"}