{"created":"2021-03-01T06:14:30.408945+00:00","id":10374,"links":{},"metadata":{"_buckets":{"deposit":"7f847027-d257-43dc-b334-5555eb6ce628"},"_deposit":{"id":"10374","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10374"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010374","sets":["453:456","471:537:538:966"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Expression of the Pentraxin 3 in Ulcerative Colitis and the Behavior of the Pentraxin 3 in Neutrophils"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"317","bibliographicPageStart":"307","bibliographicVolumeNumber":"124","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pentraxin3 (以下PTX3) は共通するC末端 domain (pentraxin domain) を有する superfamilyの一員である. 炎症や免疫において重要な役割を担い, IL-1βなどの炎症性シグナルに反応して, 炎症局所においてマクロファージや好中球, 血管内皮細胞など種々の細胞から産生されることが知られており, 炎症を鋭敏に反映する. 本研究では抗ヒト PTX3抗体を用いて, 潰瘍性大腸炎 (ulcerative colitis, 以下UC) の組織を免疫組織学的に検討してUCにおけるPTX3発現細胞を同定し, 組織学的な炎症の重症度とPTX3の関係について検討するとともに, 更に好中球におけるPTX3の動態について観察した. UCの大腸生検検体7症例 (30検体) と, 正常対照3症例 (5検体) を検討した. UCの炎症の重症度は組織学的に3段階に分類し, 抗PTX3抗体やCD15, CD68, CD163, MSR-A, CD3の各抗体を用いて免疫染色した. その結果UCにおいては炎症の組織学的な重症度が高いほど好中球を主とするPTX3陽性細胞が増加し, PTX3の発現は炎症の程度を反映することが示された. また, in vitro の実験系で蛍光染色や電子顕微鏡を用いて観察すると, PTX3は好中球の特殊顆粒内に局在し, 炎症刺激によって好中球から放出され, 炎症刺激によって形成された neutrophil extracellular traps (NETs) に結合することが確認された. NETsはUCの陰窩膿瘍にも観察され, PTX3の動態は好中球の運命と密接に関与することが明らかになった.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"71134","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Inoue, Akira"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 聡"}],"nameIdentifiers":[{"nameIdentifier":"71133","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"124(6)_307-317.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"124(6)_307-317.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10374/files/124(6)_307-317.pdf"},"version_id":"326e96aa-59db-4442-a559-0805b3b58781"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Pentraxin 3","subitem_subject_scheme":"Other"},{"subitem_subject":"潰瘍性大腸炎","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球","subitem_subject_scheme":"Other"},{"subitem_subject":"Neutrophil extracellular traps (NETs)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pentraxin 3の潰瘍性大腸炎での発現と好中球における動態に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pentraxin 3の潰瘍性大腸炎での発現と好中球における動態に関する研究"},{"subitem_title":"Pentraxin 3の潰瘍性大腸炎での発現と好中球における動態に関する研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","966"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-24"},"publish_date":"2014-07-24","publish_status":"0","recid":"10374","relation_version_is_last":true,"title":["Pentraxin 3の潰瘍性大腸炎での発現と好中球における動態に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:06.411803+00:00"}