{"created":"2021-03-01T06:14:23.234926+00:00","id":10260,"links":{},"metadata":{"_buckets":{"deposit":"91826d14-0aaa-4c7c-bcbf-ef80de9a5248"},"_deposit":{"id":"10260","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10260"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010260"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"HTRA1 controls TGF-\u03b21 Signaling Via Cleavage of pro-TGF-\u03b21: Implication for Molecular Pathogenesis of CARASIL"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"613","bibliographicPageStart":"601","bibliographicVolumeNumber":"124","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"\u8133\u5c0f\u8840\u7ba1\u75c5\u306f, \u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u826f\u304f\u898b\u3089\u308c\u308b\u75be\u60a3\u3067\u3042\u308b\u304c, \u305d\u306e\u5206\u5b50\u75c5\u614b\u6a5f\u5e8f\u306f\u4e0d\u660e\u3067\u3042\u308b. \u8fd1\u5e74\u6211\u3005\u306f, high \u2013temperature requirement A serine peptidase 1 (HTRA1) \u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c, \u907a\u4f1d\u6027\u8133\u5c0f\u8840\u7ba1\u75c5\u3067\u3042\u308b cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL: \u76ae\u8cea\u4e0b\u6897\u585e\u3068\u767d\u8cea\u8133\u75c7\u3092\u4f34\u3046\u5e38\u67d3\u8272\u4f53\u52a3\u6027\u907a\u4f1d\u6027\u8133\u52d5\u8108\u786c\u5316\u75c7) \u3092\u5f15\u304d\u8d77\u3053\u3059\u4e8b\u3092\u660e\u3089\u304b\u3068\u3057\u305f. HTRA1\u306f\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u3092\u6301\u3061, \u6d3b\u6027\u4f9d\u5b58\u6027\u306b transforming growth factor-\u03b2 (TGF-\u03b2) \u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3064. \u3053\u308c\u307e\u3067\u306b\u6211\u3005\u306f, \u75be\u60a3\u95a2\u9023\u5909\u7570\u578bHTRA1\u306fTGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3067\u304d\u305a, \u52a0\u3048\u3066CARASIL\u60a3\u8005\u306e\u8133\u4e2d\u8840\u7ba1\u306b\u304a\u3044\u3066, TGF-\u03b2\u3084TGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u306e\u4ea2\u9032\u3092\u793a\u3059EDA-Fibronectin, versican \u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u3068\u3057\u305f. \u3053\u308c\u3089\u306e\u77e5\u898b\u304b\u3089, CARASIL\u306b\u304a\u3051\u308b\u8133\u5c0f\u8840\u7ba1\u75c5\u5909\u306fTGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u306e\u4ea2\u9032\u306b\u8d77\u56e0\u3059\u308b\u3068\u7d50\u8ad6\u3057\u305f. \u3057\u304b\u3057, HTRA1\u306b\u3088\u308bTGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u306e\u6291\u5236\u6a5f\u5e8f\u306f\u660e\u3089\u304b\u3067\u306f\u306a\u3044. TGF-\u03b2\u6d3b\u6027\u306e\u8abf\u7bc0\u306f\u6b21\u306e\u3088\u3046\u306b, \u4e3b\u306b\u7d30\u80de\u5916\u3067\u884c\u308f\u308c\u308b. 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