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Glucose clamp \u6cd5\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6e2c\u5b9a\u6cd5\u3068\u3057\u3066\u6700\u3082\u4fe1\u983c\u6027\u304c\u9ad8\u3044\u3068\u3055\u308c\u308b\u304c, \u7169\u96d1\u3055\u7b49\u304b\u3089\u60a3\u8005\u53ca\u3073\u691c\u8005\u53cc\u65b9\u306b\u8ca0\u62c5\u304c\u5927\u304d\u304f, \u307e\u305f\u751f\u7406\u7684\u306a\u6761\u4ef6\u4e0b\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u8868\u3059\u3068\u306f\u5fc5\u305a\u3057\u3082\u8a00\u3048\u305a, \u5b9f\u65bd\u306f\u7814\u7a76\u76ee\u7684\u306b\u9650\u3089\u308c\u3066\u3044\u308b. Minimal model \u89e3\u6790\u6cd5\u306fBergman\u3089\u306b\u3088\u308a\u63d0\u5531\u3055\u308c insulin sensitivity \u306e\u6307\u6a19\u3068\u3057\u3066SI\u5024\u3092\u6e2c\u5b9a\u3059\u308b\u304c, \u5229\u70b9\u3068\u3057\u3066\u5168\u8eab\u6027\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u8a55\u4fa1\u53ef\u80fd, \u518d\u73fe\u6027\u304c\u9ad8\u3044, \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u30af\u30ea\u30a2\u30e9\u30f3\u30b9, Glucose effectiveness \u306a\u3069\u306e\u56e0\u5b50\u3092\u500b\u3005\u306b\u5224\u5b9a\u3067\u304d\u308b, \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u969c\u5bb3\u4f8b\u3084\u8840\u7cd6\u4e0a\u6607\u4f8b\u3067\u3082\u65bd\u884c\u53ef\u80fd\u3067\u3042\u308b\u53cd\u9762, \u6b20\u70b9\u3068\u3057\u3066\u81d3\u5668\u5225\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u8a55\u4fa1\u3067\u304d\u306a\u3044, \u7279\u6b8a\u306a\u89e3\u6790\u30bd\u30d5\u30c8\u304c\u5fc5\u8981, \u305d\u3057\u3066\u3084\u306f\u308a\u7169\u96d1\u3067\u3042\u308b\u70b9\u304c\u6319\u3052\u3089\u308c\u308b. \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6e2c\u5b9a\u3059\u308b\u7c21\u4fbf\u306a\u65b9\u6cd5\u3068\u3057\u3066, \u6700\u3082\u4e00\u822c\u7684\u306b\u7528\u3044\u3089\u308c\u308b HOMA (Homeostasis model assessment) \u306f, \u4e00\u56de\u306e\u63a1\u8840\u3067\u6e2c\u5b9a\u53ef\u80fd\u3067\u3042\u308b\u4e8b\u304b\u3089\u7c21\u4fbf\u3067\u3042\u308a\u983b\u7528\u3055\u308c\u3066\u3044\u308b\u304c, \u7a7a\u8179\u6642\u63a1\u8840\u304c\u5fc5\u8981, \u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u4f7f\u7528\u60a3\u8005\u3067\u306f\u9069\u7528\u4e0d\u53ef, \u7a7a\u8179\u6642\u8840\u7cd6\u4e0a\u6607\u4f8b\u3067\u306f\u4e0d\u6b63\u78ba\u3068\u306a\u308b\u7b49\u306e\u6b20\u70b9\u304c\u3042\u308a, \u8fd1\u5e74\u305d\u306e\u6539\u826f\u7248\u3067\u3042\u308bHOMA2\u304c\u5c0e\u5165\u3055\u308c\u305f\u304c, \u8a08\u7b97\u5f0f\u304c\u8907\u96d1\u306a\u305f\u3081, \u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u5229\u7528\u306f\u56f0\u96e3\u3067\u3042\u308b. \u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d (Hs-CRP) \u7b49\u306e\u708e\u75c7\u6027\u30de\u30fc\u30ab\u30fc\u306f\u5065\u5e38\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6307\u6a19\u3068\u3057\u3066\u306f\u6709\u7528\u3067\u3042\u308b\u304c, \u975e\u7279\u7570\u7684\u306a\u75c5\u614b\u3067\u3082\u5897\u52a0\u3057\u3046\u308b\u305f\u3081, \u5408\u4f75\u75be\u60a3\u304c\u591a\u3044\u7cd6\u5c3f\u75c5\u60a3\u8005\u3078\u306e\u9069\u7528\u306b\u306f\u9650\u754c\u304c\u3042\u308b. \u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc (LPL) \u306f, \u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308a\u305d\u306e\u8ee2\u5199, \u7ffb\u8a33, \u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e\u5404\u30ec\u30d9\u30eb\u3067\u8abf\u7bc0\u3055\u308c\u308b\u305f\u3081, \u8840\u4e2d\u6fc3\u5ea6\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u3092\u53cd\u6620\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b. \u6211\u3005\u306f\u9ad8\u611f\u5ea6\u306eLPL\u6e2c\u5b9a\u6cd5 (ELISA) \u3092\u7528\u3044\u305f\u30d8\u30d1\u30ea\u30f3\u9759\u6ce8\u524d\u8840\u6e05\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u91cf (Preheparin serum lipoprotein lipase mass: Pr-LPL) \u304c, \u5065\u5e38\u8005\u304b\u3089\u7cd6\u5c3f\u75c5\u307e\u3067\u306e\u5e83\u3044\u5bfe\u8c61\u306b\u304a\u3044\u3066SI\u3068\u6709\u610f\u306b\u76f8\u95a2\u3057, \u7279\u306b\u7a7a\u8179\u6642\u8840\u7cd6\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u75c7\u4f8b\u3084, \u30a4\u30f3\u30b9\u30ea\u30f3\u6cbb\u7642\u4e2d\u306e\u75c7\u4f8b\u306b\u304a\u3044\u3066\u3082\u9069\u7528\u53ef\u80fd\u3067\u3042\u308a, \u307e\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u306e\u5f71\u97ff\u3092\u53d7\u3051\u306a\u3044\u3053\u3068, \u660e\u3089\u304b\u306a\u65e5\u5185\u5909\u52d5\u3092\u793a\u3055\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u6765\u305f. \u3088\u3063\u3066, Pr-LPL\u306f\u8840\u7cd6\u4e0a\u6607\u4f8b, \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4f4e\u4e0b\u4f8b, \u7d4c\u53e3\u8840\u7cd6\u964d\u4e0b\u5264, \u30a4\u30f3\u30b9\u30ea\u30f3\u6cbb\u7642\u4f8b, \u98df\u5f8c\u63a1\u8840\u306b\u304a\u3044\u3066\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u53cd\u6620\u3057, HOMA, HOMA2\u3088\u308a\u9069\u5fdc\u7bc4\u56f2\u306e\u5e83\u3044\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6307\u6a19\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a, \u4eca\u5f8c\u66f4\u306a\u308b\u691c\u8a0e\u3092\u8981\u3059\u308b.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"70207","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hanyu, 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