{"_buckets": {"deposit": "7ec9c6fa-23f1-4831-b44e-7c7090d25ae6"}, "_deposit": {"id": "10102", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10102"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00010102", "sets": ["456", "957"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Study of Histopathologic Characteristics, Mucin Phenotypes and Malignant Potential of IPMN Associated with Invasive Carcinoma of the Pancreas"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "133", "bibliographicPageStart": "122", "bibliographicVolumeNumber": "125", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "膵管内乳頭粘液性腫瘍 (intraductal papillary-mucinous neoplasm: IPMN) は Gastric type (G type), Intestinal type (I type), Pancreatobiliary type (PB type), Oncocytic type (O type) の4つの組織亜型に分類され, それぞれで粘液形質 (粘液コア蛋白発現様式) が異なるとされている. 本研究では, 外科切除浸潤癌随伴IPMN 24例を対象として, IPMNの組織亜型が, IPMNの組織発生, 生物学的態度 (腫瘍のprogressionや悪性度) のいずれを反映しているかを明らかにすることを目的とした. 24は, 面積的優勢像では G typeが10/24例 (41.6%), I typeが7/24 (29.2%), PB typeが7/24 (29.2%) であったが (O typeは検討症例にはなかった), 21/24例では複数の組織亜型が混在していた. 組織亜型領域別の粘液コア蛋白発現は, G typeでは MUC5AC+/MUC2-/MUC1-が, I typeでは MUC5AC+/MUC2+/MUC1-が, PB typeでは MUC5AC+/MUC2-/MUC1+が最頻で, それぞれ各亜型の35.0%, 40.0%, 47.1%を占めたが, 各組織亜型で粘液コア蛋白発現パターンには多様性と重複があった. 組織亜型の混在パターンでは, G typeを含むものが最も多く (20/21, 95.2%), 更に同型は I type, PB typeに比べ細胞異型の低いものの頻度が高かった (各組織亜型で94.1%, 60.0%, 20.0%). IPMNの組織亜型別の生存率の比較では, PB typeが優勢像を占める浸潤癌随伴IPMNは, G type, I typeに比べ有意に予後不良であった. これらのことから, IPMNの組織亜型はIPMNの生物学的態度の違いを反映しており, IPMNは G typeを初期病変として I type, 更に PB typeにprogressionを来たすこと, PB typeのIPMNに由来する浸潤癌は G type, I typeに由来するものに比べ悪性度が高いことが推定された.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "69631", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sato, Daisuke"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "佐藤, 大輔"}], "nameIdentifiers": [{"nameIdentifier": "69630", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "125(3)_122-133.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "125(3)_122-133.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/10102/files/125(3)_122-133.pdf"}, "version_id": "c587864f-96f5-49d8-a828-62581a58a338"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "膵管内乳頭粘液性腫瘍", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IPMN", "subitem_subject_scheme": "Other"}, {"subitem_subject": "膵癌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "粘液形質", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "浸潤癌を伴う膵管内乳頭粘液性腫瘍 (IPMN) の病理組織像, 粘液形質および悪性度に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "浸潤癌を伴う膵管内乳頭粘液性腫瘍 (IPMN) の病理組織像, 粘液形質および悪性度に関する研究"}, {"subitem_title": "浸潤癌を伴う膵管内乳頭粘液性腫瘍 (IPMN) の病理組織像, 粘液形質および悪性度に関する研究", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "957"], "permalink_uri": "http://hdl.handle.net/10191/29008", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-07-28"}, "publish_date": "2014-07-28", "publish_status": "0", "recid": "10102", "relation": {}, "relation_version_is_last": true, "title": ["浸潤癌を伴う膵管内乳頭粘液性腫瘍 (IPMN) の病理組織像, 粘液形質および悪性度に関する研究"], "weko_shared_id": null}