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浸潤癌を伴う膵管内乳頭粘液性腫瘍 (IPMN) の病理組織像, 粘液形質および悪性度に関する研究
http://hdl.handle.net/10191/29008
adc1a201-16a0-4178-ab99-8d644f85e94f
| 名前 / ファイル | ライセンス | アクション | |
|---|---|---|---|
125(3)_122-133.pdf (1.9 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-28 | |||||
| タイトル | ||||||
| タイトル | 浸潤癌を伴う膵管内乳頭粘液性腫瘍 (IPMN) の病理組織像, 粘液形質および悪性度に関する研究 | |||||
| タイトル | ||||||
| 言語 | en | |||||
| タイトル | 浸潤癌を伴う膵管内乳頭粘液性腫瘍 (IPMN) の病理組織像, 粘液形質および悪性度に関する研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 膵管内乳頭粘液性腫瘍 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IPMN | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 膵癌 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 粘液形質 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Study of Histopathologic Characteristics, Mucin Phenotypes and Malignant Potential of IPMN Associated with Invasive Carcinoma of the Pancreas | |||||
| 著者 |
佐藤, 大輔
× 佐藤, 大輔 |
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| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 69631 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Sato, Daisuke | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 膵管内乳頭粘液性腫瘍 (intraductal papillary-mucinous neoplasm: IPMN) は Gastric type (G type), Intestinal type (I type), Pancreatobiliary type (PB type), Oncocytic type (O type) の4つの組織亜型に分類され, それぞれで粘液形質 (粘液コア蛋白発現様式) が異なるとされている. 本研究では, 外科切除浸潤癌随伴IPMN 24例を対象として, IPMNの組織亜型が, IPMNの組織発生, 生物学的態度 (腫瘍のprogressionや悪性度) のいずれを反映しているかを明らかにすることを目的とした. 24は, 面積的優勢像では G typeが10/24例 (41.6%), I typeが7/24 (29.2%), PB typeが7/24 (29.2%) であったが (O typeは検討症例にはなかった), 21/24例では複数の組織亜型が混在していた. 組織亜型領域別の粘液コア蛋白発現は, G typeでは MUC5AC+/MUC2-/MUC1-が, I typeでは MUC5AC+/MUC2+/MUC1-が, PB typeでは MUC5AC+/MUC2-/MUC1+が最頻で, それぞれ各亜型の35.0%, 40.0%, 47.1%を占めたが, 各組織亜型で粘液コア蛋白発現パターンには多様性と重複があった. 組織亜型の混在パターンでは, G typeを含むものが最も多く (20/21, 95.2%), 更に同型は I type, PB typeに比べ細胞異型の低いものの頻度が高かった (各組織亜型で94.1%, 60.0%, 20.0%). IPMNの組織亜型別の生存率の比較では, PB typeが優勢像を占める浸潤癌随伴IPMNは, G type, I typeに比べ有意に予後不良であった. これらのことから, IPMNの組織亜型はIPMNの生物学的態度の違いを反映しており, IPMNは G typeを初期病変として I type, 更に PB typeにprogressionを来たすこと, PB typeのIPMNに由来する浸潤癌は G type, I typeに由来するものに比べ悪性度が高いことが推定された. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 125, 号 3, p. 122-133, 発行日 2011-03 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
