2024-03-28T08:53:12Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:02000460
2022-12-15T04:16:51Z
453:455
471:561:562
Three-dimensional understanding of the morphological complexity of the human uterine endometrium
組織透明化技術によるヒト子宮内膜の立体構造の解明
Yamaguchi, Manako
山口, 真奈子
新潟大学
Niigata University
博士(医学)
The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative "endometrium-related disease," and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases.
iScience. 2021, 24(4), 102258.
新大院博(医)第1018号
doctoral thesis
2021-09-21
application/pdf
application/pdf
甲第4928号
https://niigata-u.repo.nii.ac.jp/record/2000460/files/r3nmk1018.pdf
https://niigata-u.repo.nii.ac.jp/record/2000460/files/r3nmk1018_a.pdf
eng
https://doi.org/10.1016/j.isci.2021.102258
【○!C】 2021 The Author(s).
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