2024-03-28T10:30:39Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00034160
2022-12-15T04:04:28Z
453:455
471:561:562
パレコウイルスA3とエンテロウイルスに感染した新生児・早期乳児の血清・髄液中の自然免疫反応
Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses
Habuka, Rie
178222
cerebrospinal fluid
enteroviruses
innate immunity
parechovirus-A3
serum
新潟大学
博士(医学)
Background. Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are characteristic findings. We hypothesized that innate immune responses to PeV-A3 and EV are distinct in serum and CSF. Methods. We evaluated 22 cytokines/chemokines in serum and CSF from PeV-A3- or EV-infected patients younger than 4 months in Niigata, Japan, from 2015 through 2018. Infection was diagnosed with real-time PCR followed by sequencing. Febrile neonates and infants with sepsis-like syndrome who had negative bacterial culture and viral PCR for both PeV-A and EV were also included (non-PeV-A/EV patients). Results. Among 192 febrile patients, we evaluated 16 PeV-A3-infected, 15 EV-infected, and 8 non-PeV-A/EV patients. Serum pro-/anti-inflammatory cytokine/chemokine levels were higher in PeV-A3-infected patients than in EV-infected patients (P < .02). Although most cytokine/chemokine were elevated in CSF from EV-infected patients, levels were low or undetectable in PeV-A3- infected and non-PeV-A/EV patients (P < .001). Conclusions. Distinct cytokine/chemokine patterns in serum and CSF may explain the different clinical manifestations of PeVA3-infected and EV-infected neonates and young infants.
The Journal of Infectious Diseases. 2020, 222(4), 681–689.
新大院博(医)甲第967号
thesis
2020-09-23
application/pdf
application/pdf
13101甲第4797号
https://niigata-u.repo.nii.ac.jp/record/34160/files/r2nmk967.pdf
https://niigata-u.repo.nii.ac.jp/record/34160/files/r2nmk967_a.pdf
eng
info:doi/10.1093/infdis/jiaa131
【○!C】 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.