2024-03-29T05:39:52Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00032045
2022-12-15T04:02:23Z
453:455
471:561:562
二次リンパ器官の間質細胞サブセット発生においてNF-_κB古典的経路活性化が果たす必須の役割
Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs
Essential Role of Canonical NF-_κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs
Bogdanova, Dana
175110
新潟大学
博士(医学)
Organized tissue structure in the secondary lymphoid organs (SLOs) tightly depends on the development of fibroblastic stromal cells (FSCs) of mesenchymal origin; however, the mechanisms of this relationship are poorly understood. In this study, we specifically inactivated the canonical NF-kB pathway in FSCs in vivo by conditionally inducing IkBa mutant in a Ccl19-IkBSR mouse system in which NF-kB activity is likely to be suppressed in fetal FSC progenitors. Given that NF-kB activation in fetal FSCs is essential for SLO development, the animals were expected to lack SLOs. However, all SLOs were preserved in Ccl19-IkBSR mice. Instead, the T cell area was severely disturbed by the lack of CCL21-expressing FSCs, whereas the follicles and associated FSC networks were formed. Fate mapping revealed that IkBSR-expressing cells constituted only a small fraction of stromal compartment outside the follicles. Taken together, our findings indicate an essential role of the canonical NF-kB pathway activity in the development of three FSC subsets common to SLOs and suggest transient or stochastic CCL19 expression in FSC progenitors and a compensatory differentiation program of follicular FSCs.
学位の種類: 博士(医学). 報告番号: 乙第2229号. 学位記番号: 新大博(医)乙第1801号. 学位授与年月日: 平成31年3月15日
The Journal of immunology. 2018, 201(12), 3580-3586.
新大博(医)乙第1801号
thesis
新潟大学
2019-03-15
2019-03-15
application/pdf
application/pdf
1
7
13101乙第2229号
https://niigata-u.repo.nii.ac.jp/record/32045/files/h30nmo1801.pdf
https://niigata-u.repo.nii.ac.jp/record/32045/files/h30nmo1801_a.pdf
eng
info:doi/10.4049/jimmunol.1800539
Copyright 【○!C】 2018 by The American Association of Immunologists Inc.