2024-03-29T11:09:47Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00024123
2022-12-15T03:54:17Z
453:456
471:537:538:1233
Experimental Investigation on Changes in Metabolic Turnover Rate of Glucose after 70% Hepatectomy
70%肝切除犬におけるブドウ糖代謝回転の実験的研究
70%肝切除犬におけるブドウ糖代謝回転の実験的研究
富山, 武美
144534
glucose kinetic study
6-^3H-glucose
rate of appearance of glucose
rate of disapearance of glucose
free fatty acid
total keton body
Glucose kinetics studies using 6-^3H-glucose, and measurements of serum concentration of free fatty acid and total ketone body were performed in both sham operated and 70% hepatectomized dogs. Serum glucose level was maintained 24 hours after hepatectomy by 240% increase of gluconeogenic activity of remnant liver, rather than decrease of glucose utilization of peripheral tissue. Glucose utilization of hepatectomized dogs was more enhanced than that of sham operated dogs 120 hours after the operation. In both hepatectomized group and sham operated group, a significant linear correlation between serum concentration of free fatty acid and total ketone body was found. The molecular ratio of total ketone body to free fatty acid in dogs received hepatectomy was significantly smaller than that of sham operated dogs. The results of present study-particularly, the data of hepatic glucose production rate determined by the glucose kinetics measurement-suggested that intravenous administration of 2.1~2.6mg/kg/min of glucose is the sufficient amount immediately after hepatectomy in dogs. Present study also indicated that the decreased molecular ratio of total ketone body to free fatty acid is partly due to the increased utilization of ketone bodies.
departmental bulletin paper
新潟医学会
1987-06
application/pdf
新潟医学会雑誌
6
101
390
407
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/24123/files/101(6)_390-407.pdf
jpn