2024-03-29T05:22:35Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00023453
2022-12-15T03:53:41Z
453:456
471:537:538:1221
An Immunohistological Study on Proteodermatan Sulfate in Various Liver Diseases
各種肝疾患におけるプロテオデルマタン硫酸の局在に関する検討
各種肝疾患におけるプロテオデルマタン硫酸の局在に関する検討
桧森, 昌門
141250
hepatic fibrosis
extracellular matrix
proteodermatan sulfate (PDs)
肝線維化
細胞外基質
プロテオデルマタン硫酸
Fibrotic process in liver diseases is based on the quantitative changes of extracellular matrix components. In this study, the localization of proteodermatan sulfate (PDs) was investigated in 55 cases with various liver diseases. Polyclonal antibodies to the core protein of PDs isolated and purified from human placenta, fibronectin, laminin and type III collagen were used for this purpose. Results indicated that PDs was mainly localized at the matured fibrotic areas rather than the areas of liver cell necrosis or of inflammatory cell infiltration where new fibrogenesis was predicted. These data suggest that PDs has more close interrelationship with matured collagen fibers (type I collagen) in contrast to fibronectin or type III collagen and that PDs plays an important role in the conservation of hepatic fibrosis rather than in new fibrogenesis.
departmental bulletin paper
新潟医学会
1988-06
application/pdf
新潟医学会雑誌
6
102
365
371
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/23453/files/102(6)_365-371.pdf
jpn