2024-03-29T06:59:10Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00022907
2022-12-15T03:52:40Z
453:456
471:537:538:1210
1) NGF (nerve growth factor)(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)
1) NGF (nerve growth factor)(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)
鈴木, 利光
138460
nerve growth factor
PC12h
differentiation
IGF-II
神経成長因子
分化
Nerve growth factor (NGF), of which activity had been found 40 years ago, is a typical and classical growth factor, and has been extensively studied by Rita Levi-Montalcini and her co-workers. In this symposium, we reviewed briefly tissue distribution and physiological action of NGF, and NGF-sensitive cell populations. We also described the experiments with use of PC 12h, a rat pheochromocytoma cell line which responds to not only NGF but also dbcAMP. Comparative study revealed that both agents induced morphological differentiation of PC 12h by different ways which included rapid (dbcAMP) and delayed (NGF) induction of neurite outgrowth, and difference in frequency of differentiated cells induced. Moreover, NGF did dramatically increase in the immunoreactivity of insulin-like growth factor (IGF)-II in PC 12h, whereas dbcAMP did not. This result indicated that NGF might induce morphological differentiation of PC 12h through the IGF-II produced by PC 12h under NGF-stimulation, since the IGF-II but not the NGF has been reported to augment the level of tubulin mRNAs in a human neuroblastoma cell line prior to occurrence of neurite outgrowth.
departmental bulletin paper
新潟医学会
1989-05
application/pdf
新潟医学会雑誌
5
103
337
345
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/22907/files/103(5)_337-345.pdf
jpn