2024-03-29T11:42:35Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00022771
2022-12-15T03:53:05Z
453:456
471:537:538:1205
Immunohistochemichal Analyses of Renal Lesions in Toxemia of Pregnancy
妊娠中毒症における腎病変の免疫組織学的解析
妊娠中毒症における腎病変の免疫組織学的解析
内山, 三枝子
137947
Toxemia of pregnancy
nephropathy
Immunohistochemical analyses
妊娠中毒症
腎病変
免疫組織学的解析
Toxemia of pregnancy is a disorder induced by human pregnancy, which influences the prognosis of both mother and fetus. Its etiology, however, has not yet been fully elucidated. Pregnancy per se is a naturally established allotransplantation, where fetus is not rejected by allogeneically different mother, and various sorts of immunologic phenomenon can be observed in pregnant women. And concerning toxemia of pregnancy, immunologic mechanisms might be implicated with its pathogenesis, especially with the pathogenesis of renal lesions. In this context, the renal specimens, obtained at just delivery or at puerpeirium state, were analysed by means of immunohistochemical method. Renal specimens directly biopsied from 4 patients with toxemia of pregnancy at delivery, who underwent cesarean section, and blindly biopsied from 10 patients in postpartum state. The specimens were examined by an immunoperoxidase technique using monoclonal antibodies: anti-Leul (pan T cell), anti-Leu2a (cytotoxic/suppressor T cell), anti-Leu3a (helper/inducer T cell), anti-Leu14 (B cell), anti-M3 (monocyte macrophage), anti-Leu5b (E rosette forming cell) and anti-Factor VIII related antigen (endothelial cell). In the renal tissues taken at delivery, the most prominent features in the gromeruli was swelling of endothelial cells and narrowing of capillary lumens. Infiltration of mononuclear inflammatory cells (MICs) was observed in the interstitium and also in the glomeruli. They consisted of predominatly T cells and helper/inducer cells were more commonly observed than cytotoxic/suppressor T cells. Macrophages/monocytes and B cells were observed to be present in a small number in the interstitium. IgG and IgM were located on the glomerular basement membrane in granular and/or irregular lineal pattern. These findings diminished, and became not detected by 1 month or more after delivery, except scant infiltration of MICs in the interstitium. These findings suggested that some sorts of immune reaction have an implication with the pathogenesis of renal lesion in toxemia of pregnancy. And moreover, the reversibility of the symptomes of toxemia of pregnancy might be explained by the deduction that immunologic mechanisms play an important role as a causal factor of toxemla.
departmental bulletin paper
新潟医学会
1989-10
application/pdf
新潟医学会雑誌
10
103
866
871
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/22771/files/103(10)_866-871.pdf
jpn