2024-03-29T11:08:18Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00022108
2022-12-15T03:52:30Z
453:456
471:537:538:1195
Metabolic Bone Disease in the Postoperative Pediatric Patients(Metabolic Bone Disease in Vanious Fields of Medicine)
4) 小児外科患者にみられる代謝性骨疾患(シンポジウム 各科領域での代謝性骨疾患, 第439回新潟医学会)
4) 小児外科患者にみられる代謝性骨疾患(シンポジウム 各科領域での代謝性骨疾患, 第439回新潟医学会)
広川, 恵子
134455
metabolic bone disease
biliary atresia
hepatic rickets
long term IVH
short bowel syndrome
代謝性骨疾患
胆道閉鎖症
肝性くる病
長期高カロリー輸液
短腸症候群
Eleven patients with biliary atresia (BA) were studied about bone lesion with radiological changes in bone, serum level of 25-hydroxyvitamin D (25-OH-D), alkali-posphatase (Al-P) and other serum biochemical assay. All 4 patients who have prolongation of jaundice and 6 of seven patients without jaundice had rachitic changes on radiological examinations, and pathological fracture was observed in 3 of them. The 10 rachitic patients showed low serum 25-OH-D level and high Al-P level. Serum 25-OH-D level has been increasing as their growth in the 5 patients without jaundice. The 8 of rachitic patients have been treated by oral 1,25-dihydroxyvitamin D (1,25-OH_2-D). Now radiologically rachitic changes are not revealed in 7 patients, but 4 icteric patients have osteoporotic changes. Many of BA patients, especially icteric one can not excrete bile jouce enough to absorpt vitamin D and 25 hydroxylation in the liver will be disturbed in several degree, so it is necessary to observe postoperative BA patients for long time. On the other hand, 2 patients who received long term intravenous hyperalimentation (IVH) since neonatal period because of short bowel syndrome, have developed rickets. Their serum phosphate and vitamin D levels were low and Al-P levels were elevated. By increasing the amount of intravenous administration of calcium and posphate, biochemical data was normalized and radiological rachitic changes were disappeared. We must carefully administer IVH contents to develoaping infants.
departmental bulletin paper
新潟医学会
1990-08
application/pdf
新潟医学会雑誌
8
104
635
639
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/22108/files/104(8)_635-639.pdf
jpn