2024-03-29T14:14:21Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00021953
2022-12-15T03:52:24Z
453:456
471:537:538:1193
Lyt-2^+ T cells Modify GVHR Induced by L3T4^+ T cells in MHC Class I Plus II-Disparate Hosts
Lyt-2 陽性細胞によるMHCクラスI移植細胞対宿主反応(GVHR)はL3T4陽性細胞によるMHCクラスII GVHRを制御する
Lyt-2 陽性細胞によるMHCクラスI移植細胞対宿主反応(GVHR)はL3T4陽性細胞によるMHCクラスII GVHRを制御する
五十嵐, 美徳
133580
GVHR
MHC class I
MHC class II
Lyt-2^+ cells
L3T4^+ cells
When B6 T cells are injected into unirradiated (bm1×bm12) F1 hosts, graft-versushost reactions (GVHR) are induced which are classified into two types. The one is MHC class II GVHR induced by L3T4^+ cells and the other is MHC class I GVHR by Lyt- 2^+ cells. When both L3T4^+ and Lyt-2^+ cells were injected into (bm1×bm12) F1 mice, a strong immunodeficient state was induced. Responsiveness to mitogens was abrogated. Class II GVHR showing polyclonal B cell activation was markedly suppressed by inducing class I GVHR simultaneously. The spleen cells of hosts with class II plus class I GVHR showed a marked decrease in IgM^+ cells and an increase in Thy-1^+ Lyt-2^+ cells by flowcytometric analysis. The latter population might function as suppressor and/or cytotoxic cells against host MHC antigens. Significance of the phenomena in the development of autoimmune disease is discussed.
departmental bulletin paper
新潟医学会
1990-10
application/pdf
新潟医学会雑誌
10
104
845
851
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/21953/files/104(10)_845-851.pdf
jpn