2024-03-28T11:15:27Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00021354
2022-12-15T03:51:53Z
453:456
471:537:538:1184
Recurrent Abortion and Histocompatibility Complex(Topics of lmmunogenetics)
4) 習慣流産と組織適合抗原(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)
4) 習慣流産と組織適合抗原(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)
高桑, 好一
130703
上田, 宏之
130704
山田, 潔
130705
浅野, 堅策
130706
東野, 昌彦
130707
安田, 雅子
130708
石井, 史郎
130709
風間, 芳樹
130710
金沢, 浩二
130711
田中, 憲一
130712
Recurrent abortion
Major histocompatibility complex
Immunotherapy
習慣流産
主要組織適合抗原
免疫感作療法
Reproduction is a ubiquitous and mandatory phenomenon for eternal maintenance of all species. In mammalians including human-beings, certain immunologic escape mechanisms are considered to exist when an individual has become pregnant because an embryo or fetus has paternally derived antigens which might generate immunologic rejection reaction of mother. We have previously reported the importance of Mixed Lymphocytes Culture Reaction Blocking Antibodies (MLR-BAbs) observed in normal pregnant women which inhibit maternal immune response against paternal antigens in vitro, and also reported that the MLR-BAbs were scarce or absent in most of unexplained recurrent aborters. Moreover, we elucidated the efficacy of the sensitization with husband’s lymphocytes as a treatment for immunologically explainable recurrent abortion which deliberately induced the MLR-BAbs in patients. In order to explain the lack of production of MLR-BAbs in recurrent aborters, the compatibility of HLA antigens between spouse of recurrent aborters has been examined. Although, for these two decades, the compatibility has been energetically examined by many investigators, the conclusion has not yet been obtained. In this presentation, we reported the implication of MLR-BAbs with normal pregnant women and unexplained recurrent aborters. Moreover, the results of examination of HLA antigen systems analyzed by both conventional serological method and newly developed DNA typing method were presented in order to discuss the immunogenetical aspects of recurrent abortion.
departmental bulletin paper
新潟医学会
1991-07
application/pdf
新潟医学会雑誌
7
105
452
457
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/21354/files/105(7)_452-457.pdf
jpn