2024-03-28T19:33:17Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00020874
2022-12-15T03:51:33Z
453:456
471:537:538:1172
Kinetics of Plasma Fibronectin in Childhood : Part II. Plasma Fibronectin Values in Different Types of Glomerulonephritis
小児期における血漿Fibronectinの動態に関する研究 : 第2報 各種糸球体腎炎における血漿Fibronectin値の検討
小児期における血漿Fibronectinの動態に関する研究 : 第2報 各種糸球体腎炎における血漿Fibronectin値の検討
押阪, 裕之
128393
plasma fibronectin
PSAGN
HSGN
MPGN
血漿フィブロネクチン
溶連菌感染後急性糸球体腎炎
紫斑病性腎炎
膜性増殖性腎炎
Since it has known that plasma fibronectin (FN) functions in such areas as cell adhesion, tissue repair, opsonization, or platelet coagulation, distribution in tissues or blood concentrations of plasma fibronectin has been actively studied in different types of glomerulonephritis. In this study, plasma fibronectin concentrations of patients with post-streptococcal acute glomerulonephritis (PSAGN), Henoch-Schoenlein glomerulonephritis (HSGN), and membranous proliferative glomerulonephritis (MPGN) were measured successively to examine the correlation with progress of disease. In order to standardize plasma fibronectin (p-FN) concentrations which are lower in children than adults, deviations from mean values were used for evaluation. In PSAGN, p-FN concentraions were average:372.8μg/ml and deviation:mean+0.63 SD which was within normal ranges. During the early period of illness, plasma fibronectin values were temporarily high and came down to normal quickly. In HSGN, p-FN concentrations averaged 497.5μg/ml with deviation from the mean of +2.2 SD. Both values were markedly high. While mild cases of the illness showed changes of plasma fibronectin values within nomal ranges, severe cases with hematuria or proteinuria maintained high values. In MPGN, p-FN concentrations averaged 429.6μl/ml with deviation:mean+1.4 SD, both values were relatively high which was seen throughout the course of the illness. The above results suggest that p-FN concentrations can be used in the prognosis of pediatric glomerulonephritis.
departmental bulletin paper
新潟医学会
1992-07
application/pdf
新潟医学会雑誌
7
106
649
653
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/20874/files/106(07)_649-653.pdf
jpn