2024-03-28T08:28:33Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00020872
2022-12-15T03:51:33Z
453:456
471:537:538:1172
Effects of Methylene Blue on the Relaxation and Increases in Cyclic GMP Concentrations of Vascular Smooth Muscle Produced by NO-forming Vasodilators and Atriopeptin
NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について
NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について
捧, 博輝
128389
vascular smooth muscle
NO-forming vasodilators
atriopeptin
methylene blue
cyclic GMP
血管平滑筋
心房性ナトリウム利尿ホルモン
メチレンブルー
サイクリックGMP
In the isolated endothelium-removed rabbit aorta (RA) precontracted with phenylephrine, 15 min treatment with methylene blue (15 min-MB) resulted in a rightward shift of the dose-response curve (DRC) for nitroglycerin (NTG) and nitric oxide (NO), while DRC for NaNO_2, sodium nitroprusside (SNP) and atriopeptin (ANP) was not affected. DRC for SNP was not affected in the dog coronary artery (DCA) (endothelium-removed and precontracted with KCl), while DRC for SNP was shifted to the right in the rat and guinea pig aorta. The relaxation by SNP or NaNO_2 was attenuated after 60 min-MB in RA but not in DCA. The relaxation by ANP was not affected after 60-min MB. While increases in tissue cyclic GMP in RA by NTG and NO were attenuated after 15 min-MB, the increases by SNP, NaNO_2 and ANP were not affected even after 60 min-MB. The relaxant effects of 8-Br cyclic GMP were not attenuated after 60 min-MB. Thus, the inhibition by MB of relaxation by SNP and NaNO_2 was due to its action on a process or processes operative before and/or in parallel with the accumulation of cyclic GMP. Species differences in the penetrability of MB were suggested.
departmental bulletin paper
新潟医学会
1992-07
application/pdf
新潟医学会雑誌
7
106
631
641
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/20872/files/106(07)_631-641.pdf
jpn