2024-03-29T15:35:40Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00020814
2022-12-15T04:21:07Z
453:456
471:537:538:1171
Prospective study on hemostasis activation in acute spinal cord injury patients
急性期脊髄損傷患者に於ける凝固線溶動態 : 深部静脈血栓症21例と非血栓症16例の検討
急性期脊髄損傷患者に於ける凝固線溶動態 : 深部静脈血栓症21例と非血栓症16例の検討
藤井, 幸彦
128094
spinal cord injury
deep venous thrombosis
D-dimer
thrombin antithrombin III complex
radiofibrinogen uptake test
Paralyzed patients with spinal cord injury have a high risk of deep venous thrombosis (DVT). We determined new hemostasis parameters in 37 patients and compared them with radiofibrinogen uptake test (RFUT). Blood was collected every second day for 30 days after injury. Platelet counts (PLTC), mean platelet volume (MPV), fibrinogen, von Willebrand facter antigen (VWFAg), fibrinopeptide A (FPA), thrombin/antithrombin III complex (TAT), D-dimer, platelet factor 4(PF4) and beta-thromboglobulin (BTG) were determined. Twenty-one patients (57%) developed DVT which was diagnosed by RFUT, and 9 of them were verified by venography. In PLTC, MPV, fibrinogen, VWF, FPA, PF4 and BTG, there were no significant dfferences between patients with and without DVT. However, in the first 3 weeks TAT and D-dimer levels of the patients with DVT were significantly higher than those of the patients without DVT. Seventeen out of 21 patients with DVT had the highest TAT levels before or on the first day of a positive RFUT. D-dimer levels were highest in most patients after the RFUT got positive. All patients verified by venography had remarkably high TAT (>10 ng/ml) and D-dimer levels (>3,000ng/ml). We conclude that TAT and D-dimer levels could be sensitive indicators of an ongoing DVT, and that TAT determination might predict DVT.
departmental bulletin paper
新潟医学会
1992-08
application/pdf
新潟医学会雑誌
8
106
729
738
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/20814/files/106(08)_729-738.pdf
jpn