2024-03-29T14:41:38Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00020164
2022-12-15T04:25:42Z
453:456
471:537:538:1162
Malignant Melanomas and Their Precanceroses(The Current Status and Treatment of Malignant Melanomas)
8) 悪性黒色腫とその前癌症 : 最新治療概念と今後の展望(シンポジウム 悪性黒色腫の現況と治療, 第477回新潟医学会)
8) 悪性黒色腫とその前癌症 : 最新治療概念と今後の展望(シンポジウム 悪性黒色腫の現況と治療, 第477回新潟医学会)
三嶋, 豊
124702
Malignant Melanoma
Melanoma Precanceroses
悪性黒色腫
黒色腫前癌症
Progression of human melanomas occurs by focal and multi-step oncogenesis from normal pigment cells. Accentuated melanosome-genesis accompanies this process through precancerous stages to malignant melanoma along with possible genetic alterations, which should be more fully explored for better melanoma control. Refined criteria based on new molecular to clinical analyses of lesion behavior, need to be made for each step of melanoma progression. Melanoma progression is found to be associated with a variety of structural and biochemical changes in cell surface and in cytoplasmic molecular properties, e.g. membrane carbohydrate and antigen expression dynamics, pheomelanogenesis, oncogene including suppressor gene expression, chromosome abnormalities and A^X actin synthesis. Based on these basic and clinical findings, our scheme on melanoma oncogenesis (see Table 1. in the attached Japanese section of this paper) has been elucidated.
departmental bulletin paper
新潟医学会
1993-05
application/pdf
新潟医学会雑誌
5
107
430
437
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/20164/files/107(5)_430-437.pdf
jpn