2024-03-29T12:30:23Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00020163
2022-12-15T03:50:58Z
453:456
471:537:538:1162
Activation of Extrathymic T cells in Melanoma Transgenic Mice(The Current Status and Treatment of Malignant Melanomas)
7) メラノーマと胸腺外分化T細胞(シンポジウム 悪性黒色腫の現況と治療, 第477回新潟医学会)
7) メラノーマと胸腺外分化T細胞(シンポジウム 悪性黒色腫の現況と治療, 第477回新潟医学会)
渡部, 久実
124696
飯合, 恒夫
124697
安保, 徹
124698
Extrathymic T cells
Melanoma transgenic mouse
胸腺外分化T細胞
メラノーマトランスジェニックマウス
Extrathymic T cells in mouse liver have TCR of intermediate intensity, contain doublenegative CD4^-CD8^- cells, and comprise forbidden self-reactive oligoclones. In the present study, we investigated how such extrathymic T cells were modulated during melanoma development in melanoma transgenic mice. Melanoma appeared in various organ of the transgenic mice at 15 wk of age. Extrathymic T cells with TCR of intermediate intensity increased in the liver, as the tumors advanced. Such cells infiltated the tumor lesions. In consequence of this study, it was proved that extrathymic T cells in the liver played important roles in tumor immunity.
departmental bulletin paper
新潟医学会
1993-05
application/pdf
新潟医学会雑誌
5
107
425
429
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/20163/files/107(5)_425-429.pdf
jpn