2024-03-28T16:46:48Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00019537
2022-12-15T03:50:25Z
453:456
471:537:538:1153
On the Growth, Circulation and Morphology of Extrathymically Differentiated T Cells
胸腺外分化T細胞の増殖, 循環, 形態について
胸腺外分化T細胞の増殖, 循環, 形態について
安保, 徹
121401
extrathymic T cells
liver
intermediate TCR cells
T-cell differentiation
胸腺外T細胞
肝
intermediate TCR 細胞
T細胞分化
The existence of extrathymically differentiated T cells was recently demonstrated by us and other investigators. The subsequent studies revealed that the sits where such extrathymic T cells are differentiated include the hepatic sinusoids and intraepithelial sites in the intestine. Especially, extrathymic T cells generated in the liver appear even in the organs other than the liver when they are activated. They may act rationally as a surveillance system against abnormal self, and sometimes seem to induce certain autoimmune diseases when they are over-activated. In this study, we have investigated detailed sites of extrathymic T-cell differentiation in the liver and their subsequent movements by using normal mice, congenitally athymic nude mice and autoimmune MRL-lpr/lpr mice (human SLE model).
departmental bulletin paper
新潟医学会
1994-02
application/pdf
新潟医学会雑誌
2
108
83
90
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/19537/files/108(2)_83-90.pdf
jpn