2024-03-29T14:41:58Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00019484
2022-12-15T03:50:23Z
453:456
471:537:538:1152
Sex Difference of Extrathymic T-Cells and Its Regulation by Androgen
胸腺外分化T細胞の性差とアンドロゲンによる制御
胸腺外分化T細胞の性差とアンドロゲンによる制御
木村, 元彦
121151
extrathymic T cell differentiation
intermediate TCR cells
androgen
sex difference
flow cytometry
胸腺外分化T細胞
intermediate TCR 細胞
アンドロゲン
性差
フローサイトメトリー
Male predominance of malignant disease and female predominance of autoimmune disease are widely known in humans. To elucidate one of the underlying mechanisms, we examined whether sex differences exist at the level of extrathymic T cells in various organs of mice under physiological conditions. Effects of orchiectomy or testosterone administration were also examined. Extrathymic T cells expressing CD3 of intermediate intensity (i. e., intermediate TCR cells) and a high level of IL-2 receptor β-chain (IL-2Rβ), and thymusderived T cells expressing of TCR of bright intensity (i. e., bright TCR cells) and lacking IL-2Rβ, were identified by immunofluorescent tests. Of each three strain tested, it was demonstrated that intermediate TCR cells were much more predominant in the liver and some other organs in female mice than in male mice. In the liver of orchiectomied mice, the number of mononuclear cells increasod and intermediate TCR cells became predominant as if the mice were female. Testosterone replacement canceled the immunological effect of orchiectomy. Considering the fact that extrathymic T cells comprise a considerable proportion of self-reactive forbidden clones and possess cytotoxic activity aganinst syngenic tumor cells, the present results might suggest a possible relationship between physiologically low levels of extrathymic T cells and the male predominance of malignancy.
departmental bulletin paper
新潟医学会
1994-03
application/pdf
新潟医学会雑誌
3
108
200
211
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/19484/files/108(3)_200-211.pdf
jpn