2024-03-29T00:44:12Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00019180
2022-12-15T03:50:05Z
453:456
471:537:538:1147
Cardiohemodynamic Effects of Lacidipine, a Novel Calcium Antagonist
新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用
新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用
原, 勝利
119444
石橋, 隆治
119445
濱口, 政巳
119446
今井, 昭一
119447
lacidipine
nifedipine
calcium antagonist
dog
カルシウム拮抗薬
心血行動態
心筋酸素消費量
We have examined the effects of lacidipine, a new dihydropyridine calcium antagonist, on cardiohemodynamics in comparison with those of nifedipine. Experiments were performed in open- and close-chest dogs anesthetized with morphine-α-chloralose-urethane and nitrous oxide. Lacidipine and nifedipine were administered intravenously at 1~30μg/kg. In open-chest dogs, both lacidipine and nifedipine produced dose-dependent decreases in diastolic and mean blood pressures (DBP and MBP) and increases in heart rate (HR) and left ventricular max dP/dt (LV max dP/dt). The decrease in MBP produced by nifedipine was transient; the MBP recovered to a level almost equal to the predrug level in a few minutes. In contrast, the effects of lacidipine were more prolonged except at low dose levels. On the basis of half-life assessed at a dose causing a decrement of MBP of a similar magnitude the hypotensive effect of lacidipine was >9 times longer-lasting than that of nifedipine. Both nifedipine and lacidipine decreased systolic blood pressure (SBP), left ventricular pressure (LVP) and left ventricular end-diastolic pressure (LVEDP) and increased cardiac output (CO). Lacidipine and nifedipine decreased total peripheral resistance (TPR) dose-dependently. The decreases were 20~50% for lacidipine and 15~40 % for nifedipine. Coronary blood flow (Cor-F) was increased to 50~175 % of the control after lecidipine and coronary vascular resistance (Cor-R) was decreased to 25~75%, while the changes were 40~240% and 35~70% after nifedipine. Decreases and increases were dose-dependent with both drugs. The increases in Cor-F exceeded those expected from the increases in MVO_2 observed simultaneously. In close-chest dogs, both nifedipine and lacidipine increased carotid and femoral blood flow (Car-F and Fern-F) and dose-dependently decreased carotid and femoral vascular resistance (Car-R and Fem-R). Coincident with the fall in BP renal blood flow (Ren-F) was decreased. Renal vascular resistance (Ren-R) was slightly decreased at all doses except for the maximum dose, at which it increased. The changes observed in blood flow in these vascular beds were less than 50% at the maximum and those in vascular resistance were less than 35%. Changes in MBP and HR were similar to those observed in open-chest dogs. Duration of action of lacidipine was longer than that of nifedipine. Like nifedipine the action of lacidipine was selective towards coronary artery.
departmental bulletin paper
新潟医学会
1994-08
application/pdf
新潟医学会雑誌
8
108
593
608
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/19180/files/108(8)_593-608.pdf
jpn