2024-03-29T14:46:20Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00018781
2022-12-15T03:49:53Z
453:456
471:537:538:1142
A New SPECT Ligand for Benzodiazepine Receptor Mapping with [^<123>I]-Iomazenil and its Clinical Usefulness in SPECT Studies
SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング
SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング
小田野, 行男
117279
宮下, 光太郎
117280
蓑島, 聡
117281
中島, 孝
117282
藤田, 基
117283
生田, 房弘
117284
Benzodiazepine receptor
Glucose metabolism
Neuronal cell viability
[^<123>I]-Ro 16-0154 (Iomazenil)
Parkinson's disease
ベンゾジアゼピン受容体
^<123>I-イオマゼニール
グルコース代謝
神経細胞
生存能
To determine whether low functional but viable neurons are represented by a technique for in-vivo neuroreceptor imaging, we did experiments in gerbils with cerebral infarction, in which we examined its histological changes and findings of dual tracer in-vivo autoradiography of glucose utilization with [^<14>C]-deoxyglucose and benzodiazepine receptor binding with [^<123>I]-iomazenil. The uncoupled findings of cerebral glucose metabolism and benzodiazepine receptor bindings were observed in the primary infarct lesion and in remote areas including the ipsilateral striatum and thalamus. Our experiments show that when the viable neurons with low functional activity remains intact, its situation can be demonstrated as normal in-vivo binding of benzodiazepine receptors with hypometabolism of glucose utilization. This functional contrast enhanced technique with [^<123>I]-iomazenil may play an important role to predict neuronal cell viability after recent brain infarction in experimented animals and humans with single photon emission computed tomography. The clinical usefulness of [^<123>I]-iomazenil and SPECT was also proposed in the diagnosis of the patients with chronic cerebral infarction and Parkinson's disease.
departmental bulletin paper
新潟医学会
1995-01
application/pdf
新潟医学会雑誌
1
109
1
7
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/18781/files/109(1)_1-7.pdf
jpn