2024-03-29T14:11:56Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00018197
2022-12-15T03:49:24Z
453:456
471:537:538:1131
Lipid Structure in the Water Permeability Barrier of Human Epidermis
皮膚のWater Permeability Barrierと脂質構造について
皮膚のWater Permeability Barrierと脂質構造について
山本, 綾子
114044
water permeability barrier
ceramide 1
linoleate
dry skin
atopic dermatitis
乾燥性皮膚
アトピー性皮膚炎
In any living system, control of water permeability is essential for survival. This review begins with an overview of the vast amount of work that has led to a greater understanding of the mechanisms of water permeability barrier (PB) of the stratum corneum, including the nature of stratum corneum lipids, and specifically examines the essential role of ceramides, together with the role of linoleate. The final parts of the review summarized our study of dry skin in atopic dermatitis (AD). In the study, a significant decrease in proportion of ceramide 1, which is a carrier of linoleate responsible for PB function and decreased levels of esterified linoleate of ceramide 1 were observed in AD patients.
departmental bulletin paper
新潟医学会
1996-03
application/pdf
新潟医学会雑誌
3
110
95
99
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/18197/files/110(3)_95-99.pdf
jpn